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Cntn1 contactin 1 [ Mus musculus (house mouse) ]

Gene ID: 12805, updated on 21-Apr-2024

Summary

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Official Symbol
Cntn1provided by MGI
Official Full Name
contactin 1provided by MGI
Primary source
MGI:MGI:105980
See related
Ensembl:ENSMUSG00000055022 AllianceGenome:MGI:105980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
usl; CNTN; F3cam
Summary
Enables carbohydrate binding activity. Involved in central nervous system myelin formation and locomotory behavior. Acts upstream of or within several processes, including nervous system development; positive regulation of neuron projection development; and positive regulation of sodium ion transport. Is anchored component of postsynaptic membrane. Is anchored component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; cranial ganglion; genitourinary system; and sensory organ. Used to study Compton-North congenital myopathy. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy. Orthologous to human CNTN1 (contactin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 20.9), cortex adult (RPKM 17.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 46.39 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (91949034..92239834)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (92051152..92341967)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 2 pseudogene Neighboring gene leucine-rich repeat LGI family, member 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:91964733-91964842 Neighboring gene STARR-seq mESC enhancer starr_39509 Neighboring gene predicted gene, 36901 Neighboring gene STARR-positive B cell enhancer mm9_chr15:92171487-92171788 Neighboring gene STARR-seq mESC enhancer starr_39511 Neighboring gene predicted gene, 26760 Neighboring gene predicted gene, 53194 Neighboring gene PDZ domain containing RING finger 4 Neighboring gene STARR-seq mESC enhancer starr_39512 Neighboring gene predicted gene, 52207

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma. Zhang M, et al. J Allergy Clin Immunol, 2021 Dec. PMID 33957164
  2. Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice. Puzzo D, et al. Neurobiol Aging, 2015 Apr. PMID 25659859
  3. Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system. Çolakoğlu G, et al. Proc Natl Acad Sci U S A, 2014 Jan 21. PMID 24385581, Free PMC Article
  4. F3/Contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice. Puzzo D, et al. Hippocampus, 2013 Dec. PMID 23939883
  5. Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development. Massaro A, et al. Mol Cell Neurosci, 2012 Jul. PMID 22579730

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
    Title: CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
  2. Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma.
    Title: Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma.
  3. ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
    Title: ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
  4. Contactin-1 secreted by oligodendrocytes is a novel factor that influences nodal protein clustering in hippocampus.
    Title: Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.
  5. Study confirmed that the HNK-1 epitope was primarily expressed on TNC in the embryonic day 16 mouse brain and promoted neurite outgrowth. That this signal was mediated by CNTN, which is an HNK-1-expressing neuronal receptor. These results suggest that the HNK-1 epitope is a key modifier of TNC and CNTN in the regulation of embryonic brain development.
    Title: Site-specific HNK-1 epitope on alternatively spliced fibronectin type-III repeats in tenascin-C promotes neurite outgrowth of hippocampal neurons through contactin-1.
  6. Data indicate that Contactin-1 expression is dependent upon EBF factors; Cntn1 gene belongs to the expanding regulatory cascade driven by these transcriptional regulators so that changes in its activation may contribute to the Ebf2 null mutant phenotype
    Title: The gene encoding the mouse contactin-1 axonal glycoprotein is regulated by the collier/Olf1/EBF family early B-Cell factor 2 transcription factor.
  7. It plays a role in hippocampal synaptic plasticity and memory also in aged mice, suggesting that it acts on molecular pathways related to apoptosis and amyloid-beta production.
    Title: Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice.
  8. The F3/contactin plays a role in promoting adult hippocampal neurogenesis and that this effect correlates with improved synaptic function and memory.
    Title: F3/Contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice.
  9. Contactin-1 has roles in regulating myelination and nodal/paranodal domain organization in the central nervous system
    Title: Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.
  10. In developing cerebral cortex and basal ganglia the F3/Contactin gene is mostly activated during early commitment of neuronal precursors.
    Title: Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system myelin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myelination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in myelin sheath HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
contactin-1
Names
neural cell surface protein F3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159647.2 → NP_001153119.1  contactin-1 precursor

    See identical proteins and their annotated locations for NP_001153119.1

    Status: VALIDATED

    Source sequence(s)
    AC100736, AC125460
    Consensus CDS
    CCDS27763.1
    UniProtKB/Swiss-Prot
    P12960, Q6NXV7, Q8BR42, Q8C6A0
    Related
    ENSMUSP00000067842.6, ENSMUST00000068378.6
    Conserved Domains (9) summary
    cd05851
    Location:241 → 328
    IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
    cd00063
    Location:612 → 699
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:813 → 895
    fn3; Fibronectin type III domain
    cd00096
    Location:332 → 335
    Ig; Ig strand A [structural motif]
    cd04970
    Location:503 → 603
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cd05727
    Location:142 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
    cd05849
    Location:40 → 134
    IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
    cd05852
    Location:413 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain

  2. NM_001159648.2 → NP_001153120.1  contactin-1 precursor

    See identical proteins and their annotated locations for NP_001153120.1

    Status: VALIDATED

    Source sequence(s)
    AC100736, AC125460, AC162863
    Consensus CDS
    CCDS27763.1
    UniProtKB/Swiss-Prot
    P12960, Q6NXV7, Q8BR42, Q8C6A0
    Related
    ENSMUSP00000133063.2, ENSMUST00000169825.8
    Conserved Domains (9) summary
    cd05851
    Location:241 → 328
    IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
    cd00063
    Location:612 → 699
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:813 → 895
    fn3; Fibronectin type III domain
    cd00096
    Location:332 → 335
    Ig; Ig strand A [structural motif]
    cd04970
    Location:503 → 603
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cd05727
    Location:142 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
    cd05849
    Location:40 → 134
    IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
    cd05852
    Location:413 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain

  3. NM_001358051.2 → NP_001344980.1  contactin-1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC100736, AC125460, AC162863
    Consensus CDS
    CCDS27763.1
    UniProtKB/Swiss-Prot
    P12960, Q6NXV7, Q8BR42, Q8C6A0
    Conserved Domains (9) summary
    cd05851
    Location:241 → 328
    IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
    cd00063
    Location:612 → 699
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:813 → 895
    fn3; Fibronectin type III domain
    cd00096
    Location:332 → 335
    Ig; Ig strand A [structural motif]
    cd04970
    Location:503 → 603
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cd05727
    Location:142 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
    cd05849
    Location:40 → 134
    IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
    cd05852
    Location:413 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain

  4. NM_001411171.1 → NP_001398100.1  contactin-1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC100736, AC125460, AC162863
    UniProtKB/Swiss-Prot
    P12960, Q6NXV7, Q8BR42, Q8C6A0

  5. NM_007727.3 → NP_031753.1  contactin-1 precursor

    See identical proteins and their annotated locations for NP_031753.1

    Status: VALIDATED

    Source sequence(s)
    AC100736, AC125460, AC162863
    Consensus CDS
    CCDS27763.1
    UniProtKB/Swiss-Prot
    P12960, Q6NXV7, Q8BR42, Q8C6A0
    Related
    ENSMUSP00000000109.5, ENSMUST00000000109.11
    Conserved Domains (9) summary
    cd05851
    Location:241 → 328
    IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
    cd00063
    Location:612 → 699
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:813 → 895
    fn3; Fibronectin type III domain
    cd00096
    Location:332 → 335
    Ig; Ig strand A [structural motif]
    cd04970
    Location:503 → 603
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cd05727
    Location:142 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
    cd05849
    Location:40 → 134
    IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
    cd05852
    Location:413 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    91949034..92239834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520383.5 → XP_006520446.1  contactin-1 isoform X2

    Conserved Domains (6) summary
    cd05727
    Location:134 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
    cd05849
    Location:40 → 132
    Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
    cd05851
    Location:241 → 328
    Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
    cd05852
    Location:429 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cd04970
    Location:520 → 604
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain

  2. XM_036159111.1 → XP_036015004.1  contactin-1 isoform X1

    UniProtKB/Swiss-Prot
    P12960, Q6NXV7, Q8BR42, Q8C6A0
    Conserved Domains (9) summary
    cd05851
    Location:241 → 328
    IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
    cd00063
    Location:612 → 699
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:813 → 895
    fn3; Fibronectin type III domain
    cd00096
    Location:332 → 335
    Ig; Ig strand A [structural motif]
    cd04970
    Location:503 → 603
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cd05727
    Location:142 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
    cd05849
    Location:40 → 134
    IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
    cd05852
    Location:413 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain

  3. XM_017316423.3 → XP_017171912.1  contactin-1 isoform X2

    Conserved Domains (6) summary
    cd05727
    Location:134 → 230
    Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
    cd05849
    Location:40 → 132
    Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
    cd05851
    Location:241 → 328
    Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
    cd05852
    Location:429 → 501
    Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
    cd04970
    Location:520 → 604
    Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:332 → 408
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12960.1 GenPept UniProtKB/Swiss-Prot:P12960

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