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LOC127826926 H3K27ac hESC enhancer GRCh37_chr13:111368201-111368894 [ Homo sapiens (human) ]

Gene ID: 127826926, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127826926
Gene description
H3K27ac hESC enhancer GRCh37_chr13:111368201-111368894
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes three accessible chromatin subregions, two of which were validated as silencers and one as an enhancer based on their ability to repress or activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (110715767..110716547)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (109945971..109946751)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111266973-111267900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8004 Neighboring gene NAXD antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111284913-111285575 Neighboring gene NAD(P)HX dehydratase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111286570-111287399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111287400-111288228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111289059-111289887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111301435-111301934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5508 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8011 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111364717-111364885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111371617-111372308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8015 Neighboring gene inhibitor of growth family member 1 Neighboring gene ribosomal protein L21 pseudogene 107 Neighboring gene uncharacterized LOC107984613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 8014
  • ATAC-STARR-seq lymphoblastoid silent region 5516
  • ATAC-STARR-seq lymphoblastoid silent region 5517

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_128431.2 

    Range
    101..881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    110715767..110716547
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    109945971..109946751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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