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LOC127817245 OCT4-NANOG hESC enhancer GRCh37_chr10:12524423-12525029 [ Homo sapiens (human) ]

Gene ID: 127817245, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127817245
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr10:12524423-12525029
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127817245 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (12482424..12483030)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (12494725..12495331)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent protein kinase ID Neighboring gene RNA, U6atac small nuclear 39, pseudogene Neighboring gene uncharacterized LOC107984209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12531623-12532583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12594952-12595452 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:12595691-12595888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3047 Neighboring gene microRNA 4480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12680729-12681229 Neighboring gene microRNA 4481

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_118728.1 

    Range
    101..707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    12482424..12483030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    12494725..12495331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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