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Cxcr2 C-X-C motif chemokine receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12765, updated on 7-Apr-2024

Summary

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Official Symbol
Cxcr2provided by MGI
Official Full Name
C-X-C motif chemokine receptor 2provided by MGI
Primary source
MGI:MGI:105303
See related
Ensembl:ENSMUSG00000026180 AllianceGenome:MGI:105303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH
Summary
Enables chemokine receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C3; 1 38.41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74193153..74200405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74153994..74161246)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene VISTA enhancer mm1630 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E9467 Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene microRNA 1928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth. Yang J, et al. Mol Cancer, 2023 Jun 3. PMID 37270599, Free PMC Article
  2. CXCR2 intrinsically drives the maturation and function of neutrophils in mice. Delobel P, et al. Front Immunol, 2022. PMID 36311783, Free PMC Article
  3. CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice. La Cognata V, et al. Neurobiol Dis, 2021 Dec. PMID 34743985
  4. CXCR1/2 Inhibitor Ladarixin Ameliorates the Insulin Resistance of 3T3-L1 Adipocytes by Inhibiting Inflammation and Improving Insulin Signaling. Castelli V, et al. Cells, 2021 Sep 6. PMID 34571976, Free PMC Article
  5. Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms. Shi X, et al. Nat Commun, 2021 May 5. PMID 33953162, Free PMC Article

See all (343) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-kappaB signaling in diabetic kidney disease.
    Title: Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.
  2. Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis.
    Title: Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis.
  3. Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary fibrosis in mice exposed to silica.
    Title: Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary fibrosis in mice exposed to silica.
  4. CXCR2 antagonism attenuates neuroinflammation after subarachnoid hemorrhage.
    Title: CXCR2 antagonism attenuates neuroinflammation after subarachnoid hemorrhage.
  5. CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
    Title: CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
  6. CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth.
    Title: CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth.
  7. Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.
    Title: Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.
  8. CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut-brain axis.
    Title: CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut-brain axis.
  9. CXCR2 intrinsically drives the maturation and function of neutrophils in mice.
    Title: CXCR2 intrinsically drives the maturation and function of neutrophils in mice.
  10. CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration.
    Title: CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration.
Submit: New GeneRIF Correction See all GeneRIFs (182)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-8 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-8 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-8 receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular defense response ISO
Inferred from Sequence Orthology
more info
  
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-8-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in metanephric tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mast cell granule ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
GRO/MGSA receptor
IL-8 receptor alpha chain
IL-8R B
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009909.3 → NP_034039.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_034039.1

    Status: VALIDATED

    Source sequence(s)
    AC117757, CJ056061
    Consensus CDS
    CCDS15040.1
    UniProtKB/Swiss-Prot
    P35343, Q53X27
    Related
    ENSMUSP00000102512.3, ENSMUST00000106899.4
    Conserved Domains (1) summary
    cd15178
    Location:48 → 324
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74193153..74200405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495638.5 → XP_006495701.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_006495701.1

    UniProtKB/Swiss-Prot
    P35343, Q53X27
    Conserved Domains (1) summary
    cd15178
    Location:48 → 324
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35343.1 GenPept UniProtKB/Swiss-Prot:P35343

Gene LinkOut

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