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Clk4 CDC like kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 12750, updated on 21-Apr-2024

Summary

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Official Symbol
Clk4provided by MGI
Official Full Name
CDC like kinase 4provided by MGI
Primary source
MGI:MGI:1098551
See related
Ensembl:ENSMUSG00000020385 AllianceGenome:MGI:1098551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Acts upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Located in nucleus. Is expressed in several structures, including endocrine gland; gonad; hemolymphoid system gland; liver; and tongue. Orthologous to human CLK4 (CDC like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 17.6), CNS E11.5 (RPKM 16.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.02 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51153941..51172597)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51263114..51281770)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 20 Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5223 Neighboring gene Myb/SANT DNA binding domain containing 5 like Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51347850-51348150 Neighboring gene STARR-positive B cell enhancer ABC_E6980 Neighboring gene STARR-seq mESC enhancer starr_29416 Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene heterogeneous nuclear ribonucleoprotein A/B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a 3-Mb contig and partial transcript map of the central region of mouse chromosome 11. Watkins-Chow DE, et al. Genomics, 1997 Oct 1. PMID 9339371
  2. CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Huang J, et al. Nat Commun, 2022 Jul 30. PMID 35907876, Free PMC Article
  3. Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. Hartmann AM, et al. Mol Cell Neurosci, 2001 Jul. PMID 11461155
  4. Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor. Ninomiya K, et al. J Cell Biol, 2011 Oct 3. PMID 21949414, Free PMC Article
  5. Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. Katsu R, et al. J Biol Chem, 2002 Nov 15. PMID 12169693

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation.
    Title: CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation.
  2. Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins.
    Title: Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein kinase CLK4
NP_001291673.1
NP_001349464.1
NP_001349465.1
NP_001349467.1
NP_001349468.1
NP_001349469.1
NP_001349470.1
NP_031740.1
XP_006532175.1
XP_006532177.1
XP_006532181.1
XP_011247010.1
XP_017169732.1
XP_030101370.1
XP_030101371.1
XP_036012164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304744.1 → NP_001291673.1  dual specificity protein kinase CLK4 isoform 2

    See identical proteins and their annotated locations for NP_001291673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    UniProtKB/Swiss-Prot
    O35493
    Related
    ENSMUSP00000104741.2, ENSMUST00000109113.8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001362535.1 → NP_001349464.1  dual specificity protein kinase CLK4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Conserved Domains (1) summary
    cd14213
    Location:149 → 478
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  3. NM_001362536.1 → NP_001349465.1  dual specificity protein kinase CLK4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  4. NM_001362538.1 → NP_001349467.1  dual specificity protein kinase CLK4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  5. NM_001362539.1 → NP_001349468.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001362540.1 → NP_001349469.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001362541.1 → NP_001349470.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  8. NM_007714.6 → NP_031740.1  dual specificity protein kinase CLK4 isoform 1

    See identical proteins and their annotated locations for NP_031740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS24651.1
    UniProtKB/Swiss-Prot
    O35493, O35721, Q8CEU9, Q99LU6
    UniProtKB/TrEMBL
    Q4FJV9
    Related
    ENSMUSP00000090820.7, ENSMUST00000093132.13
    Conserved Domains (1) summary
    cd14213
    Location:146 → 475
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51153941..51172597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532118.3 → XP_006532181.1  dual specificity protein kinase CLK4 isoform X4

    See identical proteins and their annotated locations for XP_006532181.1

    UniProtKB/Swiss-Prot
    O35493
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006532112.5 → XP_006532175.1  dual specificity protein kinase CLK4 isoform X3

    See identical proteins and their annotated locations for XP_006532175.1

    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  3. XM_030245511.2 → XP_030101371.1  dual specificity protein kinase CLK4 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006532114.5 → XP_006532177.1  dual specificity protein kinase CLK4 isoform X4

    See identical proteins and their annotated locations for XP_006532177.1

    UniProtKB/Swiss-Prot
    O35493
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  5. XM_017314243.2 → XP_017169732.1  dual specificity protein kinase CLK4 isoform X1

    Conserved Domains (1) summary
    cd14213
    Location:175 → 504
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  6. XM_036156271.1 → XP_036012164.1  dual specificity protein kinase CLK4 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030245510.2 → XP_030101370.1  dual specificity protein kinase CLK4 isoform X3

    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  8. XM_011248708.4 → XP_011247010.1  dual specificity protein kinase CLK4 isoform X2

    Conserved Domains (1) summary
    cd14213
    Location:155 → 484
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35493.1 GenPept UniProtKB/Swiss-Prot:O35493

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