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LOC127400434 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:23887769-23888345 [ Homo sapiens (human) ]

Gene ID: 127400434, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127400434
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:23887769-23888345
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (23886146..23886722)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (23867904..23868480)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374528 Neighboring gene uncharacterized LOC124900680 Neighboring gene uncharacterized LOC105374527 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:23789763-23790962 Neighboring gene PPARG coactivator 1 alpha Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_77881 Neighboring gene VISTA enhancer hs2346 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:23933777-23934617 Neighboring gene NANOG hESC enhancer GRCh37_chr4:23974350-23974892 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:23981005-23981707 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:24000845-24002044 Neighboring gene NANOG hESC enhancer GRCh37_chr4:24031602-24032103 Neighboring gene Sharpr-MPRA regulatory region 2780 Neighboring gene Sharpr-MPRA regulatory region 10171 Neighboring gene uncharacterized LOC124900679 Neighboring gene NANOG hESC enhancer GRCh37_chr4:24268492-24268993 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:24323096-24323895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24332192-24332760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24350443-24351174 Neighboring gene NANOG hESC enhancer GRCh37_chr4:24414779-24415480 Neighboring gene uncharacterized LOC124900678

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_102397.1 

    Range
    101..677
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    23886146..23886722
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    23867904..23868480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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