Chl1 cell adhesion molecule L1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chl1provided by MGI
Official Full Name: cell adhesion molecule L1-likeprovided by MGI
Primary source: MGI:MGI:1098266
See related: Ensembl:ENSMUSG00000030077 AllianceGenome:MGI:1098266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CALL; LICAM2; A530023M13Rik
Summary: Enables protease binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including adult locomotory behavior; exploration behavior; and generation of neurons. Located in apical part of cell and dendrite. Is expressed in nervous system and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHL1 (cell adhesion molecule L1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 40.0), whole brain E14.5 (RPKM 21.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E1; 6 47.97 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (103487372..103709999)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (103510584..103733038)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
Title: Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
Cell adhesion molecule close homolog of L1 binds to the dopamine receptor D2 and inhibits the internalization of its short isoform.
Title: Cell adhesion molecule close homolog of L1 binds to the dopamine receptor D2 and inhibits the internalization of its short isoform.
CHL1 promotes insulin secretion and negatively regulates the proliferation of pancreatic beta cells.
Title: CHL1 promotes insulin secretion and negatively regulates the proliferation of pancreatic β cells.
Close homolog of L1-deficient ameliorates inflammatory bowel disease by regulating the balance of Th17/Treg.
Title: Close homolog of L1-deficient ameliorates inflammatory bowel disease by regulating the balance of Th17/Treg.
Spine and excitatory synapse density of pyramidal neurons in the developing neocortex is regulated by CHL1. CHL1 mediated spine pruning in response to the secreted repellent ligand Semaphorin 3B and associated with receptor subunits Neuropilin-2 and PlexinA4. Loss of CHL1 in nullmice resulted in increased spine density and a greater proportion of immature spines on apical dendrites in the prefrontal and visual cortices.
Title: Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B.
ADAM10 enhances BACE1-mediated CHL1 proteolysis.
Title: α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
here we identify a number of novel roles for CHL1 in establishment of the midbrain dopamine pathways, functions that are reinforced by evidence in other neuronal networks, yet roles that are also unique to this discrete population of neurons. Supported by spatial and temporal expression within the VM, and validated in CHL1 deficient mice.
Title: Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways.
The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner.
Title: Tumor-dependent secretion of close homolog of L1 results in elevation of its circulating level in mouse model for human lung tumor.
investigated temporal discounting in CHL1-deficient (KO) mice and their wild-type littermates. Although no discounting differences were found under baseline conditions, CHL1-KO mice showed increased impulsive choice following chronic unpredictable stress (fewer % larger-later choices, and reduced area under the discounting curve). Impulsive choice alterations were reversed by the 5-HT2C agonist Ro 60-0175.
Title: Increased temporal discounting after chronic stress in CHL1-deficient mice is reversed by 5-HT2C agonist Ro 60-0175.
The results of the present study indicate that CHL1 triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development.
Title: The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI465420 (e-PCR)
- UniSTS:159550

Chl1 (e-PCR), detects polymorphism
- UniSTS:531331

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: neural cell adhesion molecule L1-like protein

Names: cell adhesion molecule with homology to L1CAM; chl1-like protein; close homolog of L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007697.2 → NP_031723.2 neural cell adhesion molecule L1-like protein precursor

See identical proteins and their annotated locations for NP_031723.2

Status: VALIDATED

Source sequence(s)

AC153595, AK040765, X94310

Consensus CDS

CCDS39582.1

UniProtKB/Swiss-Prot

A2RRK1, P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7

Related

ENSMUSP00000063933.7, ENSMUST00000066905.9

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1105 → 1186

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

103487372..103709999

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505467.4 → XP_006505530.1 neural cell adhesion molecule L1-like protein isoform X1

See identical proteins and their annotated locations for XP_006505530.1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_006505473.4 → XP_006505536.1 neural cell adhesion molecule L1-like protein isoform X3

See identical proteins and their annotated locations for XP_006505536.1

Conserved Domains (8) summary

smart00409
Location:548 → 624

IG; Immunoglobulin

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1067 → 1148

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_017321377.3 → XP_017176866.1 neural cell adhesion molecule L1-like protein isoform X4

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1051 → 1132

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_036165791.1 → XP_036021684.1 neural cell adhesion molecule L1-like protein isoform X1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_036165793.1 → XP_036021686.1 neural cell adhesion molecule L1-like protein isoform X2

UniProtKB/Swiss-Prot

A2RRK1, P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1105 → 1186

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_006505471.4 → XP_006505534.1 neural cell adhesion molecule L1-like protein isoform X1

See identical proteins and their annotated locations for XP_006505534.1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_006505472.4 → XP_006505535.1 neural cell adhesion molecule L1-like protein isoform X2

See identical proteins and their annotated locations for XP_006505535.1

UniProtKB/Swiss-Prot

A2RRK1, P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1105 → 1186

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_006505470.4 → XP_006505533.1 neural cell adhesion molecule L1-like protein isoform X1

See identical proteins and their annotated locations for XP_006505533.1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_011241198.4 → XP_011239500.1 neural cell adhesion molecule L1-like protein isoform X3

See identical proteins and their annotated locations for XP_011239500.1

Related

ENSMUSP00000145026.2, ENSMUST00000203912.3

Conserved Domains (8) summary

smart00409
Location:548 → 624

IG; Immunoglobulin

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1067 → 1148

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_030255132.2 → XP_030110992.1 neural cell adhesion molecule L1-like protein isoform X2

UniProtKB/Swiss-Prot

A2RRK1, P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1105 → 1186

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_006505469.4 → XP_006505532.1 neural cell adhesion molecule L1-like protein isoform X1

See identical proteins and their annotated locations for XP_006505532.1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_036165795.1 → XP_036021688.1 neural cell adhesion molecule L1-like protein isoform X4

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1051 → 1132

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_030255131.2 → XP_030110991.1 neural cell adhesion molecule L1-like protein isoform X1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_017321376.3 → XP_017176865.1 neural cell adhesion molecule L1-like protein isoform X2

UniProtKB/Swiss-Prot

A2RRK1, P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1105 → 1186

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_030255133.2 → XP_030110993.1 neural cell adhesion molecule L1-like protein isoform X2

UniProtKB/Swiss-Prot

A2RRK1, P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7

Conserved Domains (8) summary

smart00410
Location:532 → 608

IG_like; Immunoglobulin like

cd00063
Location:612 → 701

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:715 → 795

fn3; Fibronectin type III domain

pfam13882
Location:1105 → 1186

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:258 → 262

Ig; Ig strand B [structural motif]

cd04978
Location:332 → 419

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:246 → 328

Ig; Immunoglobulin domain
XM_036165792.1 → XP_036021685.1 neural cell adhesion molecule L1-like protein isoform X1

Conserved Domains (8) summary

smart00410
Location:548 → 624

IG_like; Immunoglobulin like

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1121 → 1202

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain
XM_036165794.1 → XP_036021687.1 neural cell adhesion molecule L1-like protein isoform X3

Conserved Domains (8) summary

smart00409
Location:548 → 624

IG; Immunoglobulin

cd00063
Location:628 → 717

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:731 → 811

fn3; Fibronectin type III domain

pfam13882
Location:1067 → 1148

Bravo_FIGEY; Bravo-like intracellular region

cd00096
Location:274 → 278

Ig; Ig strand B [structural motif]

cd04978
Location:348 → 435

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

cd05845
Location:135 → 225

IgI_2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:262 → 344

Ig; Immunoglobulin domain