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Cdc7 cell division cycle 7 [ Mus musculus (house mouse) ]

Gene ID: 12545, updated on 21-Apr-2024

Summary

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Official Symbol
Cdc7provided by MGI
Official Full Name
cell division cycle 7provided by MGI
Primary source
MGI:MGI:1309511
See related
Ensembl:ENSMUSG00000029283 AllianceGenome:MGI:1309511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc7l1; muCdc7
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including double-strand break repair via break-induced replication; peptidyl-serine phosphorylation; and positive regulation of cell cycle process. Predicted to act upstream of or within cell division and phosphorylation. Predicted to be located in intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; musculature; nervous system; and sensory organ. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 17.6), limb E14.5 (RPKM 17.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E5; 5 51.43 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107112201..107132298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (106964315..106984440)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33327 Neighboring gene STARR-seq mESC enhancer starr_13877 Neighboring gene HFM1, ATP-dependent DNA helicase homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:107320773-107320956 Neighboring gene STARR-positive B cell enhancer ABC_E4773 Neighboring gene STARR-seq mESC enhancer starr_13878 Neighboring gene olfactory receptor 719, pseudogene Neighboring gene STARR-seq mESC enhancer starr_13879 Neighboring gene STARR-seq mESC enhancer starr_13880 Neighboring gene STARR-seq mESC enhancer starr_13882 Neighboring gene predicted gene, 33371 Neighboring gene predicted gene, 33474

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDC7-independent G1/S transition revealed by targeted protein degradation. Suski JM, et al. Nature, 2022 May. PMID 35508654, Free PMC Article
  2. Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis. Kim JM, et al. EMBO J, 2003 Oct 1. PMID 14517263, Free PMC Article
  3. Identification and characterization of mouse homologue to yeast Cdc7 protein and chromosomal localization of the cognate mouse gene Cdc7l. Faul T, et al. Chromosoma, 1999 Apr. PMID 10199953
  4. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for s. cerevisiae Cdc7-related kinase. Kim JM, et al. J Biol Chem, 1998 Sep 4. PMID 9722556
  5. Cell division cycle 7 mediates transforming growth factor-β-induced smooth muscle maturation through activation of myocardin gene transcription. Shi N, et al. J Biol Chem, 2013 Nov 29. PMID 24133205, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc7 kinase is required for postnatal brain development.
    Title: Cdc7 kinase is required for postnatal brain development.
  2. CDC7-independent G1/S transition revealed by targeted protein degradation.
    Title: CDC7-independent G1/S transition revealed by targeted protein degradation.
  3. Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins.
    Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.
  4. Increased Cdc7-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.
    Title: p53 gain-of-function mutations increase Cdc7-dependent replication initiation.
  5. Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity
    Title: Cell division cycle 7 mediates transforming growth factor-β-induced smooth muscle maturation through activation of myocardin gene transcription.
  6. Cdc7 mediates SMC differentiation through a mechanism distinct from cell proliferation.
    Title: Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation.
  7. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin
    Title: Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91067

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle 7-related protein kinase
Names
CDC7-related kinase
cell division cycle 7-like 1
NP_001258495.1
NP_001258496.1
NP_001258497.1
NP_001407653.1
NP_001407654.1
NP_001407655.1
NP_033993.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271566.2 → NP_001258495.1  cell division cycle 7-related protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001258495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC134409
    Consensus CDS
    CCDS19498.1
    UniProtKB/Swiss-Prot
    Q9WUV1, Q9Z0H0, Q9Z2Y7
    Related
    ENSMUSP00000113385.2, ENSMUST00000118261.8
    Conserved Domains (2) summary
    cd14019
    Location:50 → 429
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:337 → 559
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001271567.2 → NP_001258496.1  cell division cycle 7-related protein kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform (1).
    Source sequence(s)
    AC134409
    Consensus CDS
    CCDS71628.1
    UniProtKB/Swiss-Prot
    Q9Z0H0
    Related
    ENSMUSP00000112392.3, ENSMUST00000117196.9
    Conserved Domains (2) summary
    cd14019
    Location:50 → 397
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:305 → 527
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001271568.2 → NP_001258497.1  cell division cycle 7-related protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001258497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks an alternate in-frame exon and uses an alternate in-frame acceptor splice site in the coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform (1).
    Source sequence(s)
    AC134409
    Consensus CDS
    CCDS71629.1
    UniProtKB/TrEMBL
    Q66JY4
    Related
    ENSMUSP00000075792.7, ENSMUST00000076467.13
    Conserved Domains (1) summary
    cd14019
    Location:50 → 390
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

  4. NM_001420724.1 → NP_001407653.1  cell division cycle 7-related protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134409

  5. NM_001420725.1 → NP_001407654.1  cell division cycle 7-related protein kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134409

  6. NM_001420726.1 → NP_001407655.1  cell division cycle 7-related protein kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134409

  7. NM_009863.4 → NP_033993.2  cell division cycle 7-related protein kinase isoform 1

    See identical proteins and their annotated locations for NP_033993.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC134409
    Consensus CDS
    CCDS19498.1
    UniProtKB/Swiss-Prot
    Q9WUV1, Q9Z0H0, Q9Z2Y7
    Related
    ENSMUSP00000031221.6, ENSMUST00000031221.12
    Conserved Domains (2) summary
    cd14019
    Location:50 → 429
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:337 → 559
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107112201..107132298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0H0.2 GenPept UniProtKB/Swiss-Prot:Q9Z0H0

Gene LinkOut

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