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Cdc45 cell division cycle 45 [ Mus musculus (house mouse) ]

Gene ID: 12544, updated on 21-Apr-2024

Summary

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Official Symbol
Cdc45provided by MGI
Official Full Name
cell division cycle 45provided by MGI
Primary source
MGI:MGI:1338073
See related
Ensembl:ENSMUSG00000000028 AllianceGenome:MGI:1338073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc45l
Summary
Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Predicted to act upstream of or within DNA replication. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of DNA replication preinitiation complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and notochord. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 24.8), liver E14 (RPKM 24.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 11.63 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18599202..18632371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18780447..18811972, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41428 Neighboring gene claudin 5 Neighboring gene STARR-positive B cell enhancer ABC_E763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18812268-18812501 Neighboring gene predicted gene, 52240 Neighboring gene RIKEN cDNA 2510002D24 gene Neighboring gene STARR-positive B cell enhancer ABC_E10892 Neighboring gene ubiquitin recognition factor in ER-associated degradation 1 Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene histone cell cycle regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cdc45 is a critical effector of myc-dependent DNA replication stress. Srinivasan SV, et al. Cell Rep, 2013 May 30. PMID 23643534, Free PMC Article
  2. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L. Kunte A, et al. Mech Dev, 2001 Oct. PMID 11578863
  3. Requirement of CDC45 for postimplantation mouse development. Yoshida K, et al. Mol Cell Biol, 2001 Jul. PMID 11416137, Free PMC Article
  4. Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. Shaikh TH, et al. Mamm Genome, 1999 Mar. PMID 10051334
  5. Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. McKie JM, et al. Genome Res, 1998 Aug. PMID 9724329, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DONSON is required for CMG helicase assembly in the mammalian cell cycle.
    Title: DONSON is required for CMG helicase assembly in the mammalian cell cycle.
  2. Cdc45 Recapitulates Myc-Dependent DNA Replication Stress.
    Title: Cdc45 is a critical effector of myc-dependent DNA replication stress.
  3. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin
    Title: Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cell division control protein 45 homolog
Names
CDC45-related protein
PORC-PI-1
cell division cycle 45 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161623.3 → NP_001155095.1  cell division control protein 45 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC083895
    Consensus CDS
    CCDS49788.1
    UniProtKB/TrEMBL
    F8WJ72, Q3TIH7
    Related
    ENSMUSP00000094753.4, ENSMUST00000096990.10
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 515
    CDC45; CDC45-like protein

  2. NM_001358206.2 → NP_001345135.1  cell division control protein 45 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC083895
    Consensus CDS
    CCDS28027.1
    UniProtKB/Swiss-Prot
    O70547, Q9QUK1, Q9R212, Q9Z1X9
    UniProtKB/TrEMBL
    Q3TIH7, Q3UI99
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 561
    CDC45; CDC45-like protein

  3. NM_001416648.1 → NP_001403577.1  cell division control protein 45 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC083895

  4. NM_001416649.1 → NP_001403578.1  cell division control protein 45 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC083895

  5. NM_001416651.1 → NP_001403580.1  cell division control protein 45 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC083895

  6. NM_001416660.1 → NP_001403589.1  cell division control protein 45 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC083895

  7. NM_001416663.1 → NP_001403592.1  cell division control protein 45 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC083895

  8. NM_009862.3 → NP_033992.2  cell division control protein 45 homolog isoform 1

    See identical proteins and their annotated locations for NP_033992.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC083895
    Consensus CDS
    CCDS28027.1
    UniProtKB/Swiss-Prot
    O70547, Q9QUK1, Q9R212, Q9Z1X9
    UniProtKB/TrEMBL
    Q3TIH7, Q3UI99
    Related
    ENSMUSP00000000028.8, ENSMUST00000000028.14
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 561
    CDC45; CDC45-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18599202..18632371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159760.1 → XP_036015653.1  cell division control protein 45 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70547, Q9QUK1, Q9R212, Q9Z1X9
    UniProtKB/TrEMBL
    Q3TIH7, Q3UI99
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 561
    CDC45; CDC45-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1X9.2 GenPept UniProtKB/Swiss-Prot:Q9Z1X9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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