Cd81 CD81 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd81provided by MGI
Official Full Name: CD81 antigenprovided by MGI
Primary source: MGI:MGI:1096398
See related: Ensembl:ENSMUSG00000037706 AllianceGenome:MGI:1096398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tapa1; Tapa-1; Tspan28
Summary: Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of immune response; and syncytium formation by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 806.6), ovary adult (RPKM 391.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.1 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142606487..142621667)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (143052750..143067930)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The molecular mechanism of CD81 antibody inhibition of metastasis.
Title: The molecular mechanism of CD81 antibody inhibition of metastasis.
Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus accumbens modulates anxiety and ethanol-related behaviors.
Title: Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus accumbens modulates anxiety and ethanol-related behaviors.
The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication.
Title: The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication.
CD81 marks immature and dedifferentiated pancreatic beta-cells.
Title: CD81 marks immature and dedifferentiated pancreatic β-cells.
Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
Title: Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
Title: CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
CD9 and CD81 might coordinately prevent senescence and inflammation, partly by maintaining SIRT1 expression. Altogether, CD9/CD81 DKO mice represent a novel model for both COPD and accelerated senescence.
Title: Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.
The species-specific traits in CD9 and CD81 distribution during sperm maturation were compared between mice and humans. A mutual position of CD9/CD81 is shown in human spermatozoa in the acrosomal cap, however in mice, CD9 and CD81 occupy a distinct area.
Title: CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization.
adoptive transfer of wild-type regulatory T cells into CD81-deficient mice was sufficient to promote tumor growth and metastasis; these findings suggested that CD81 modulates adaptive and innate immune responses
Title: Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells.
CD81-Rac interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases.
Title: CD81 controls immunity to Listeria infection through rac-dependent inhibition of proinflammatory mediator release and activation of cytotoxic T cells.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127728 (e-PCR)
- UniSTS:211038

Cd81 (e-PCR), detects polymorphism
- UniSTS:516462

Cd81 (e-PCR), detects polymorphism
- UniSTS:532164

Cd81 (e-PCR), detects polymorphism
- UniSTS:141295

Cd81 (e-PCR), detects polymorphism
- UniSTS:141296

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class II protein binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell costimulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in macrophage fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage fusion	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adaptive immune memory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process in the vacuole	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell motility	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD81 antigen

Names: 26 kDa cell surface protein TAPA-1; target of the antiproliferative antibody 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133655.2 → NP_598416.1 CD81 antigen

See identical proteins and their annotated locations for NP_598416.1

Status: VALIDATED

Source sequence(s)

AK166521, BQ175686, BQ175800, BY252638

Consensus CDS

CCDS22038.1

UniProtKB/Swiss-Prot

P35762, Q91V78

UniProtKB/TrEMBL

Q3UWG5

Related

ENSMUSP00000043768.10, ENSMUST00000037941.10

Conserved Domains (2) summary

cd03151
Location:113 → 202

CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:9 → 230

Tetraspannin; Tetraspanin family