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Cd72 CD72 antigen [ Mus musculus (house mouse) ]

Gene ID: 12517, updated on 21-Apr-2024

Summary

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Official Symbol
Cd72provided by MGI
Official Full Name
CD72 antigenprovided by MGI
Primary source
MGI:MGI:88345
See related
Ensembl:ENSMUSG00000028459 AllianceGenome:MGI:88345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD72c; Ly-19; Ly-32; Lyb-2; Ly-m19
Summary
Predicted to enable carbohydrate binding activity and transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebellum external granule cell layer; cerebellum internal granule cell layer; hippocampus; and neocortex. Orthologous to human CD72 (CD72 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 30.9), testis adult (RPKM 10.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 23.04 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43447724..43454708, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43447724..43455102, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene predicted gene, 52698 Neighboring gene STARR-seq mESC enhancer starr_10053 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene testis specific protein kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:43495064-43495217 Neighboring gene STARR-positive B cell enhancer ABC_E834 Neighboring gene suppression inducing transmembrane adaptor 1 Neighboring gene RNA component of mitochondrial RNAase P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of peripheral B cell tolerance by CD72 in a murine model. Li DH, et al. Arthritis Rheum, 2008 Oct. PMID 18821699, Free PMC Article
  2. CD72 down-modulates BCR-induced signal transduction and diminishes survival in primary mature B lymphocytes. Li DH, et al. J Immunol, 2006 May 1. PMID 16621999
  3. Dual regulation of BCR-mediated growth inhibition signaling by CD72. Baba T, et al. Eur J Immunol, 2005 May. PMID 15816000
  4. Partial cDNA sequences of bovine CD72 and CD166/ALCAM, ligands for SRCR-family accessory molecules CD5 and CD6. Rogers AN, et al. Vet Immunol Immunopathol, 2002 Mar. PMID 11943324
  5. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Pan C, et al. Immunity, 1999 Oct. PMID 10549631

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD22 and CD72 contribute to the development of scleroderma in a murine model.
    Title: CD22 and CD72 contribute to the development of scleroderma in a murine model.
  2. Reverse Arthus reaction model in the skin was induced in mice lacking CD22 (CD22-/-), CD72 (CD72-/-), and both of them (CD22-/-/CD72-/-) by immune complex challenge. Results demonstrate that CD22 and CD72 expression contribute to the development of the reverse Arthus reaction model and CD22 and CD72 might be therapeutic targets for human IC-mediated diseases.
    Title: CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model.
  3. CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP.
    Title: CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.
  4. CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha.
    Title: CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.
  5. CD5 and CD72 play a critical role in maintaining regulatory T and B cell homeostasis
    Title: Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis.
  6. These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr)-induced autoimmune disease due to its reduced activity of B cell signal regulation.
    Title: Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease.
  7. Cd72 polymorphism affects susceptibility to lupus phenotypes.
    Title: A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice.
  8. CD72 is an inhibitory receptor on NK cells regulating cytokine production.
    Title: B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity.
  9. CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance
    Title: Modulation of peripheral B cell tolerance by CD72 in a murine model.
  10. Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response.
    Title: Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
B-cell differentiation antigen CD72
Names
lymphocyte antigen 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110320.2 → NP_001103790.1  B-cell differentiation antigen CD72 isoform 1

    See identical proteins and their annotated locations for NP_001103790.1

    Status: VALIDATED

    Source sequence(s)
    AL732506
    Consensus CDS
    CCDS51166.1
    UniProtKB/TrEMBL
    Q3UZ35, Q99L55
    Related
    ENSMUSP00000030179.5, ENSMUST00000030179.11
    Conserved Domains (2) summary
    smart00034
    Location:232 → 348
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl12013
    Location:137 → 209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001110321.2 → NP_001103791.1  B-cell differentiation antigen CD72 isoform 3

    See identical proteins and their annotated locations for NP_001103791.1

    Status: VALIDATED

    Source sequence(s)
    AL732506
    Consensus CDS
    CCDS51165.1
    UniProtKB/TrEMBL
    Q3UNJ0, Q99L55
    Related
    ENSMUSP00000095709.4, ENSMUST00000098105.4
    Conserved Domains (2) summary
    smart00034
    Location:208 → 324
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl12013
    Location:113 → 185
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001110322.2 → NP_001103792.1  B-cell differentiation antigen CD72 isoform 4

    See identical proteins and their annotated locations for NP_001103792.1

    Status: VALIDATED

    Source sequence(s)
    AL732506
    Consensus CDS
    CCDS51164.1
    UniProtKB/TrEMBL
    Q3UB58, Q99L55
    Related
    ENSMUSP00000095708.4, ENSMUST00000098104.10
    Conserved Domains (2) summary
    smart00034
    Location:178 → 287
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl12013
    Location:83 → 155
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_001419973.1 → NP_001406902.1  B-cell differentiation antigen CD72 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732506

  5. NM_001419974.1 → NP_001406903.1  B-cell differentiation antigen CD72 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732506

  6. NM_001419975.1 → NP_001406904.1  B-cell differentiation antigen CD72 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL732506

  7. NM_001419976.1 → NP_001406905.1  B-cell differentiation antigen CD72 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL732506

  8. NM_001419977.1 → NP_001406906.1  B-cell differentiation antigen CD72 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL732506
    UniProtKB/TrEMBL
    A2AIN5

  9. NM_001419978.1 → NP_001406907.1  B-cell differentiation antigen CD72 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL732506

  10. NM_007654.3 → NP_031680.2  B-cell differentiation antigen CD72 isoform 2

    See identical proteins and their annotated locations for NP_031680.2

    Status: VALIDATED

    Source sequence(s)
    AL732506
    Consensus CDS
    CCDS38740.1
    UniProtKB/Swiss-Prot
    A2AIN6, P21855, Q64225
    UniProtKB/TrEMBL
    Q99L55
    Related
    ENSMUSP00000103559.2, ENSMUST00000107926.8
    Conserved Domains (2) summary
    smart00034
    Location:232 → 341
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl12013
    Location:137 → 209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43447724..43454708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537578.5 → XP_006537641.1  B-cell differentiation antigen CD72 isoform X3

    UniProtKB/TrEMBL
    Q99L55
    Conserved Domains (2) summary
    smart00034
    Location:240 → 356
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    COG1196
    Location:121 → 230
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006537582.3 → XP_006537645.1  B-cell differentiation antigen CD72 isoform X6

    See identical proteins and their annotated locations for XP_006537645.1

    Conserved Domains (2) summary
    smart00034
    Location:127 → 243
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    COG1196
    Location:28 → 117
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006537581.3 → XP_006537644.1  B-cell differentiation antigen CD72 isoform X6

    See identical proteins and their annotated locations for XP_006537644.1

    Conserved Domains (2) summary
    smart00034
    Location:127 → 243
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    COG1196
    Location:28 → 117
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21855.2 GenPept UniProtKB/Swiss-Prot:P21855

Gene LinkOut

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