Cd7 CD7 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd7provided by MGI
Official Full Name: CD7 antigenprovided by MGI
Primary source: MGI:MGI:88344
See related: Ensembl:ENSMUSG00000025163 AllianceGenome:MGI:88344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within homeostasis of number of cells within a tissue. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; hemolymphoid system gland; intestine; liver and biliary system; and reproductive system. Orthologous to human CD7 (CD7 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 29.9), duodenum adult (RPKM 18.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120927573..120930304, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121036747..121039478, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD7 chimeric antigen receptor T cells have robust activity against T-cell malignancies in vitro and in vivo.
Title: CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.
Data indicate the tissue ligand SECTM1A (Secreted and transmembrane1A) as an alternative CD7 ligand.
Title: Secreted and transmembrane 1A is a novel co-stimulatory ligand.
Molecular mimicry of murine CD7 with HSP-60 is demonstrated; CD7 may regulate HSP-60 expression in mouse small intestine.
Title: Murine CD7 shares antigenic cross-reactivity with HSP-60.
The regulation of CD7 gene expression through NF-kappaB activation induced by TCR/CD28 might have significant implications for T-cell homeostasis.
Title: CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation.
differential levels of CD7 identify the progressive stages of lineage commitment in human thymus, initiated from a primitive CD7(-) lympho-myeloid thymic progenitor
Title: Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.
Data demonstrate collaborative roles for both CD7 and CD28 in determination of number and function of CD4+CD25+ T regulatory cells in the thymus and peripheral immune sites and in the development of spontaneous thyroiditis.
Title: CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd7 (e-PCR), detects polymorphism
- UniSTS:141294

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell antigen CD7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.