Cd63 CD63 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd63provided by MGI
Official Full Name: CD63 antigenprovided by MGI
Primary source: MGI:MGI:99529
See related: Ensembl:ENSMUSG00000025351 AllianceGenome:MGI:99529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ME491; Tspan30
Summary: Involved in pigment cell differentiation and regulation of vascular endothelial growth factor signaling pathway. Located in late endosome and lysosome. Is expressed in blood vessel; brain; eye anterior segment; and intestine. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 201.9), placenta adult (RPKM 183.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.19 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128731577..128748691)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128896231..128912822)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In renal proximal tubules, CD63 determines the insertion of OCT2 into the proper membrane domain and mediates transporter regulation by trafficking processes.
Title: Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules.
TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.
Title: Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.
The Muted protein is important for the steady-state level of CD63.
Title: Muted protein is involved in the targeting of CD63 to large dense-core vesicles of chromaffin cells.
Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity.
Title: Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization.
These findings identify CD63 as an important component of allergic inflammation.
Title: The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.
CD63 serves to bridge between beta1 integrin and VEGFR2 because CD63 silencing disrupted VEGFR2-beta1 integrin complex formation identified using proximity ligation assay
Title: Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.
Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis.
Title: The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.
Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin.
Title: CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.
CXCR4 can be downregulated on activated B cells by IL-21-induced endocytosis and CD63-mediated endosomal recruitment.
Title: CXCR4 expression on activated B cells is downregulated by CD63 and IL-21.
The findings identify palmitoylation-dependent association with the tetraspanin CD63 as the mechanism by which Syt VII is targeted to lysosomes.
Title: Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126796 (e-PCR)
- UniSTS:209741

RH125938 (e-PCR)
- UniSTS:162650

RH139213 (e-PCR)
- UniSTS:221299

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in pigment cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment granule maturation	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome lumen	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD63 antigen

Names: melanoma 1 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042580.2 → NP_001036045.1 CD63 antigen

See identical proteins and their annotated locations for NP_001036045.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.

Source sequence(s)

AC122380

Consensus CDS

CCDS24297.1

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q3UC80, Q549D0

Related

ENSMUSP00000100862.2, ENSMUST00000105229.9

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
NM_001282966.2 → NP_001269895.1 CD63 antigen

See identical proteins and their annotated locations for NP_001269895.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.

Source sequence(s)

AC122380

Consensus CDS

CCDS24297.1

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q3UC80, Q549D0

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
NM_001428408.1 → NP_001415337.1 CD63 antigen

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.

Source sequence(s)

AC122380

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q549D0
NM_001428409.1 → NP_001415338.1 CD63 antigen

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.

Source sequence(s)

AC122380

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q549D0
NM_007653.4 → NP_031679.1 CD63 antigen

See identical proteins and their annotated locations for NP_031679.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.

Source sequence(s)

AC122380

Consensus CDS

CCDS24297.1

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q3UC80, Q549D0

Related

ENSMUSP00000026407.8, ENSMUST00000026407.9

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128731577..128748691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155570.1 → XP_036011463.1 CD63 antigen isoform X1

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q3UC80, Q549D0

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
XM_030244852.1 → XP_030100712.1 CD63 antigen isoform X1

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q3UC80, Q549D0

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family
XM_030244851.1 → XP_030100711.1 CD63 antigen isoform X1

UniProtKB/Swiss-Prot

P41731

UniProtKB/TrEMBL

Q3UC80, Q549D0

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family