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Cd5 CD5 antigen [ Mus musculus (house mouse) ]

Gene ID: 12507, updated on 5-Mar-2024

Summary

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Official Symbol
Cd5provided by MGI
Official Full Name
CD5 antigenprovided by MGI
Primary source
MGI:MGI:88340
See related
Ensembl:ENSMUSG00000024669 AllianceGenome:MGI:88340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-1; Ly-A; Ly-12; Lyt-1
Summary
Predicted to enable scavenger receptor activity. Acts upstream of or within T cell costimulation and apoptotic signaling pathway. Located in external side of plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human CD5 (CD5 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 77.3), spleen adult (RPKM 17.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Cd5 in Genome Data Viewer
Location:
19 A; 19 7.16 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10695471..10716390, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10718107..10739026, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene vacuolar protein sorting 37C Neighboring gene RIKEN cDNA A430093F15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10861955-10862189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10862842-10863029 Neighboring gene CD6 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10903953-10904062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10904315-10904608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells. Schuster C, et al. Front Immunol, 2022. PMID 35720357, Free PMC Article
  2. CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice. Dong M, et al. Immunol Cell Biol, 2021 Jul. PMID 33534942
  3. CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens. Blaize G, et al. Proc Natl Acad Sci U S A, 2020 Jun 9. PMID 32434911, Free PMC Article
  4. CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity. Alotaibi F, et al. Eur J Immunol, 2020 May. PMID 31943150
  5. CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses. Li H, et al. PLoS One, 2019. PMID 31491023, Free PMC Article

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice.
    Title: CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice.
  2. CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity.
    Title: CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity.
  3. CD5 dynamically calibrates basal NF-kappaB signaling in T cells during thymic development and peripheral activation.
    Title: CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.
  4. Collectively, these data demonstrate that the specific expression of CD5 on dendritic cells inhibits the production of inflammatory cytokines and has a regulatory effect on their activity to stimulate T cells and induce immune responses.
    Title: CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.
  5. A novel role for BTK in regulating CD1d(hi)CD5(+) Breg differentiation.
    Title: BTK signaling drives CD1d(hi)CD5(+) regulatory B-cell differentiation to promote pancreatic carcinogenesis.
  6. Binding studies show that both soluble and membrane-bound forms of CD5 and CD6 bind to intact viable protoscoleces from E. granulosus s.l. through recognition of metaperiodate-resistant tegumental components.
    Title: The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis.
  7. The natural substrate for the cell surface sialidase was identified as clustered differentiation 5 (CD5) by PNA-blot analysis of anti-CD5 immunoprecipitate.
    Title: Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5.
  8. FasL expression in splenic CD5(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 ligation.
    Title: TLR4 supports the expansion of FasL(+)CD5(+)CD1d(hi) regulatory B cells, which decreases in contact hypersensitivity.
  9. CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals
    Title: CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.
  10. the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.
    Title: CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell surface glycoprotein CD5
Names
lymphocyte antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007650.3 → NP_031676.3  T-cell surface glycoprotein CD5 precursor

    See identical proteins and their annotated locations for NP_031676.3

    Status: VALIDATED

    Source sequence(s)
    AC132247, AI528619, AK143736
    Consensus CDS
    CCDS29586.1
    UniProtKB/Swiss-Prot
    P13379
    UniProtKB/TrEMBL
    Q3UP78, Q91X69
    Related
    ENSMUSP00000025571.8, ENSMUST00000025571.9
    Conserved Domains (2) summary
    smart00202
    Location:34 → 133
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:168 → 268
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10695471..10716390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526621.2 → XP_006526684.1  T-cell surface glycoprotein CD5 isoform X1

    UniProtKB/TrEMBL
    A0A494BB49
    Related
    ENSMUSP00000158313.2, ENSMUST00000238167.2
    Conserved Domains (1) summary
    smart00202
    Location:34 → 133
    SR; Scavenger receptor Cys-rich
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13379.1 GenPept UniProtKB/Swiss-Prot:P13379

Gene LinkOut

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