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Cbr2 carbonyl reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 12409, updated on 11-Apr-2024

Summary

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Official Symbol
Cbr2provided by MGI
Official Full Name
carbonyl reductase 2provided by MGI
Primary source
MGI:MGI:107200
See related
Ensembl:ENSMUSG00000025150 AllianceGenome:MGI:107200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLCR
Summary
Enables carbonyl reductase (NADPH) activity; identical protein binding activity; and protein self-association. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Predicted to act upstream of or within NADH oxidation. Located in mitochondrion. Is expressed in alimentary system; heart; nervous system; nose; and respiratory system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 3180.6) and bladder adult (RPKM 108.6) See more
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Genomic context

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See Cbr2 in Genome Data Viewer
Location:
11 E2; 11 84.47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120620311..120622851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120729485..120732025, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rac family small GTPase 3 Neighboring gene STARR-positive B cell enhancer ABC_E5314 Neighboring gene dicarbonyl L-xylulose reductase Neighboring gene high mobility group AT-hook 1B Neighboring gene NADPH-dependent carbonyl reductase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid. Nakanishi M, et al. J Biol Chem, 1997 Jan 24. PMID 8999926
  2. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Tanaka N, et al. Structure, 1996 Jan 15. PMID 8805511
  3. Ultrastructural localization of carbonyl reductase in mouse lung. Matsuura K, et al. Histochem J, 1994 Apr. PMID 8040004
  4. Cloning, expression and tissue distribution of mouse tetrameric carbonyl reductase. Identity with an adipocyte 27-kDa protein. Nakanishi M, et al. Eur J Biochem, 1995 Mar 1. PMID 7705352
  5. A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation. Navre M, et al. J Cell Biol, 1988 Jul. PMID 2455724, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-xylulose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonyl reductase (NADPH) activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within NADH oxidation TAS
Traceable Author Statement
more info
 PubMed 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xylulose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
carbonyl reductase [NADPH] 2
Names
AP27
LCR
NADPH-dependent carbonyl reductase 2
adipocyte protein P27
lung carbonyl reductase
NP_031647.1
XP_006532159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007621.2 → NP_031647.1  carbonyl reductase [NADPH] 2

    See identical proteins and their annotated locations for NP_031647.1

    Status: VALIDATED

    Source sequence(s)
    AK081816, BF730701, BY118518
    Consensus CDS
    CCDS25756.1
    UniProtKB/Swiss-Prot
    P08074
    UniProtKB/TrEMBL
    Q542P5
    Related
    ENSMUSP00000026148.3, ENSMUST00000026148.9
    Conserved Domains (1) summary
    cd05351
    Location:1 → 244
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120620311..120622851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532096.2 → XP_006532159.1  carbonyl reductase [NADPH] 2 isoform X1

    UniProtKB/TrEMBL
    F6YNX9
    Related
    ENSMUSP00000117739.2, ENSMUST00000154565.2
    Conserved Domains (1) summary
    cl21454
    Location:1 → 181
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08074.1 GenPept UniProtKB/Swiss-Prot:P08074

Gene LinkOut

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