Capza2 capping actin protein of muscle Z-line subunit alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Capza2provided by MGI
Official Full Name: capping actin protein of muscle Z-line subunit alpha 2provided by MGI
Primary source: MGI:MGI:106222
See related: Ensembl:ENSMUSG00000015733 AllianceGenome:MGI:106222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cappa2; 1110053K06Rik
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping. Located in brush border; cortical cytoskeleton; and membrane. Part of F-actin capping protein complex. Is expressed in nervous system; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 63.7), frontal lobe adult (RPKM 46.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A2; 6 7.96 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (17637009..17666971)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (17637010..17666972)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

ECD20142 (e-PCR)
- UniSTS:301146

AW208808 (e-PCR)
- UniSTS:179337

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of F-actin capping protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-actin-capping protein subunit alpha-2

Names: capZ alpha-2; capping protein (actin filament) muscle Z-line, alpha 2; capping protein alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.