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Calu calumenin [ Mus musculus (house mouse) ]

Gene ID: 12321, updated on 5-Mar-2024

Summary

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Official Symbol
Caluprovided by MGI
Official Full Name
calumeninprovided by MGI
Primary source
MGI:MGI:1097158
See related
Ensembl:ENSMUSG00000029767 AllianceGenome:MGI:1097158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530075H20Rik
Summary
Enables calcium ion binding activity. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and immune system. Orthologous to human CALU (calumenin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 120.1), limb E14.5 (RPKM 116.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29348105..29376674)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29348106..29376675)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene STARR-seq mESC enhancer starr_15437 Neighboring gene golgi associated RAB2 interactor 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29297688-29297797 Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Neighboring gene nuclear encoded tRNA proline 6 (anticodon AGG) Neighboring gene blue cone (S) opsin upstream regulatory region Neighboring gene coiled-coil domain containing 136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of isoforms and genomic organization of mouse calumenin. Jung DH, et al. Gene, 2004 Mar 3. PMID 14980715
  2. Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Wang Q, et al. Oncogene, 2015 Feb 19. PMID 24632605
  3. Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum. Sahoo SK, et al. J Biol Chem, 2009 Nov 6. PMID 19740751, Free PMC Article
  4. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. Yabe D, et al. Genomics, 1998 Apr 15. PMID 9598325
  5. Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain. Vasiljevic M, et al. Neuroscience, 2012 Jan 27. PMID 22178608, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular calumenin regulates fibulin-1 to have crucial roles in ERK1/2 signaling and cell migration.
    Title: Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis.
  2. This study points to a possible important role of calumenin in migration and differentiation of neurons
    Title: Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain.
  3. Regions of 132-222 amino acids of calumenin and 853-892 amino acids of SERCA2 are the major binding partners.
    Title: Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calumenin
Names
crocalbin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285412.1 → NP_001272341.1  calumenin isoform 3

    See identical proteins and their annotated locations for NP_001272341.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate splice site in the 5' coding region, resulting in a distinct 5' UTR and initiation of translation from a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC044807
    UniProtKB/TrEMBL
    G3V004
    Related
    ENSMUSP00000134708.2, ENSMUST00000173216.8
    Conserved Domains (2) summary
    cd15899
    Location:4 → 33
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:1 → 148
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

  2. NM_007594.4 → NP_031620.1  calumenin isoform 1 precursor

    See identical proteins and their annotated locations for NP_031620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK135295, AK148178, AK163674, CJ084197
    Consensus CDS
    CCDS19957.1
    UniProtKB/Swiss-Prot
    O35887
    UniProtKB/TrEMBL
    Q3TUF3, Q3UG11
    Related
    ENSMUSP00000031779.11, ENSMUST00000031779.17
    Conserved Domains (1) summary
    cd16228
    Location:37 → 299
    EFh_CREC_Calumenin; EF-hand, calcium binding motif, found in calumenin

  3. NM_184053.3 → NP_908942.1  calumenin isoform 2 precursor

    See identical proteins and their annotated locations for NP_908942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and contains a different alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which contains a different internal segment, compared to isoform 1.
    Source sequence(s)
    AK135295, AK147756, AK148178, AK163674, CJ084197
    Consensus CDS
    CCDS19958.1
    UniProtKB/TrEMBL
    Q3TL33, Q6XLQ8
    Related
    ENSMUSP00000087967.8, ENSMUST00000090481.14
    Conserved Domains (1) summary
    cd16228
    Location:37 → 299
    EFh_CREC_Calumenin; EF-hand, calcium binding motif, found in calumenin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29348105..29376674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165784.1 → XP_036021677.1  calumenin isoform X1

    Conserved Domains (2) summary
    cd15899
    Location:1 → 27
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:1 → 225
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35887.1 GenPept UniProtKB/Swiss-Prot:O35887

Gene LinkOut

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