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C4bp complement component 4 binding protein [ Mus musculus (house mouse) ]

Gene ID: 12269, updated on 3-Apr-2024

Summary

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Official Symbol
C4bpprovided by MGI
Official Full Name
complement component 4 binding proteinprovided by MGI
Primary source
MGI:MGI:88229
See related
Ensembl:ENSMUSG00000026405 AllianceGenome:MGI:88229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C4bpa
Summary
Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to act upstream of or within complement activation, classical pathway and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 182.0) and liver adult (RPKM 75.8) See more
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Genomic context

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Location:
1 E4; 1 56.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130562510..130589365, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130635921..130661657, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene zona pellucida 3 receptor Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene STARR-seq mESC enhancer starr_02199 Neighboring gene predicted gene, 23623 Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein, pseudogene 1 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1230 Neighboring gene YOD1 deubiquitinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation. Bierschenk D, et al. Front Immunol, 2023. PMID 37283747, Free PMC Article
  2. C4b binding protein negatively regulates TLR1/2 response. Morita N, et al. Innate Immun, 2017 Jan. PMID 27794068
  3. Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility. Nonaka MI, et al. Immunobiology, 2015 Apr. PMID 25468721, Free PMC Article
  4. Complement C4b-binding protein as a novel murine epididymal secretory protein. Nonaka MI, et al. Biol Reprod, 2003 Dec. PMID 12930719
  5. Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex. Kaidoh T, et al. Proc Natl Acad Sci U S A, 1981 Jun. PMID 6943584, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation.
    Title: C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation.
  2. The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.
    Title: The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.
  3. Data suggest that C4bp prevents interaction between Tlr4/MD-2 and its ligand; C4bp does not appear to interact with Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 activation. (C4bp = complement component 4 binding protein; Tlr = toll-like receptor; MD-2 = myeloid differentiation protein-2)
    Title: C4b-binding protein negatively regulates TLR4/MD-2 response but not TLR3 response.
  4. this study shows that C4BP binds to TLR2, inhibits TLR1/2 ligand binding and reduces cytokine production
    Title: C4b binding protein negatively regulates TLR1/2 response.
  5. These results suggest that EpC4BP is involved in male reproduction, but not essential for sperm maturation.
    Title: Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility.
  6. The cellular uptake of C4BP depends on both heparan sulfate proteoglycans and CD91, involving interactions with positively charged residues within C4BP alpha-chain.
    Title: Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein.
  7. a novel function of C4BP as an epididymal secretory protein
    Title: Complement C4b-binding protein as a novel murine epididymal secretory protein.
  8. findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor-related protein
    Title: Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity.
  9. C4BP prevents premature clearance of protein S and uses this ability to compensate the increased clearance of protein S-S460P.
    Title: In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of opsonization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to symbiotic bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C4b-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419982.1 → NP_001406911.1  C4b-binding protein isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231
    UniProtKB/Swiss-Prot
    P08607, Q91X48

  2. NM_001419983.1 → NP_001406912.1  C4b-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231

  3. NM_001419984.1 → NP_001406913.1  C4b-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231

  4. NM_001419986.1 → NP_001406915.1  C4b-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231

  5. NM_001419987.1 → NP_001406916.1  C4b-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231

  6. NM_001419988.1 → NP_001406917.1  C4b-binding protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231

  7. NM_007576.4 → NP_031602.3  C4b-binding protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_031602.3

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC139231
    Consensus CDS
    CCDS35700.1
    UniProtKB/Swiss-Prot
    P08607, Q91X48
    UniProtKB/TrEMBL
    Q3UW06
    Related
    ENSMUSP00000027657.8, ENSMUST00000027657.14
    Conserved Domains (3) summary
    PHA02831
    Location:290 → 420
    PHA02831; EEV host range protein; Provisional
    PHA02927
    Location:43 → 299
    PHA02927; secreted complement-binding protein; Provisional
    pfam18453
    Location:416 → 464
    C4bp_oligo; Oligomerization domain of C4b-binding protein alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130562510..130589365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247906.2 → XP_011246208.1  C4b-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011246208.1

    UniProtKB/Swiss-Prot
    P08607, Q91X48
    UniProtKB/TrEMBL
    Q3UW06
    Conserved Domains (3) summary
    PHA02831
    Location:290 → 420
    PHA02831; EEV host range protein; Provisional
    PHA02927
    Location:43 → 299
    PHA02927; secreted complement-binding protein; Provisional
    pfam18453
    Location:416 → 464
    C4bp_oligo; Oligomerization domain of C4b-binding protein alpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08607.3 GenPept UniProtKB/Swiss-Prot:P08607

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