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ASB3 ankyrin repeat and SOCS box containing 3 [ Panthera leo (lion) ]

Gene ID: 122216048, updated on 22-Mar-2024

Summary

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Gene symbol
ASB3
Gene description
ankyrin repeat and SOCS box containing 3
See related
EnsemblRapid:ENSPLXG00005004261
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera leo
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: A3
Exon count:
13
Annotation release Status Assembly Chr Location
100 current P.leo_Ple1_pat1.1 (GCF_018350215.1) A3 NC_056681.1 (72226844..72340741, complement)

Chromosome A3 - NC_056681.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC122215028 Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene U12 minor spliceosomal RNA Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2 Neighboring gene endoplasmic reticulum lectin 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056681.1 Chromosome A3 Reference P.leo_Ple1_pat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera leo Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.leo_Ple1_pat1.1 Primary Assembly

Genomic

  1. NC_056681.1 Reference P.leo_Ple1_pat1.1 Primary Assembly

    Range
    72226844..72340741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042932259.1 → XP_042788193.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 398
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_042932261.1 → XP_042788195.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 398
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_042932258.1 → XP_042788192.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 398
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_042932262.1 → XP_042788196.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 398
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_042932260.1 → XP_042788194.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 398
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_042932257.1 → XP_042788191.1  ankyrin repeat and SOCS box protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 398
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:459 → 509
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_042932263.1 → XP_042788197.1  ankyrin repeat and SOCS box protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Related
    ENSPLXP00005005191.1, ENSPLXT00005008827.1
    Conserved Domains (4) summary
    PHA02876
    Location:83 → 397
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    cl39094
    Location:22 → 237
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_042932264.1 → XP_042788198.1  ankyrin repeat and SOCS box protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C9CZ61
    Conserved Domains (4) summary
    PHA02876
    Location:25 → 340
    PHA02876; ankyrin repeat protein; Provisional
    cd03722
    Location:401 → 451
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:88 → 118
    ANK; ANK repeat [structural motif]
    cl39094
    Location:13 → 179
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
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