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Bmi1 Bmi1 polycomb ring finger oncogene [ Mus musculus (house mouse) ]

Gene ID: 12151, updated on 22-Apr-2024

Summary

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Official Symbol
Bmi1provided by MGI
Official Full Name
Bmi1 polycomb ring finger oncogeneprovided by MGI
Primary source
MGI:MGI:88174
See related
Ensembl:ENSMUSG00000026739 AllianceGenome:MGI:88174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmi-1; Pcgf4
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; histone modification; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PcG protein complex and ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 11.2), testis adult (RPKM 11.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 12.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18681953..18691440)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18677018..18686629)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 50498 Neighboring gene ATP synthase subunit f, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_03812 Neighboring gene COMM domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E5891 Neighboring gene predicted gene, 46725 Neighboring gene sperm associated antigen 6 Neighboring gene predicted gene 3363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells. Jiang ZY, et al. World J Gastroenterol, 2023 Jun 21. PMID 37398890, Free PMC Article
  2. BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b/β-catenin signaling. Yu J, et al. Int J Biol Sci, 2022. PMID 35541907, Free PMC Article
  3. The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1. Zhou H, et al. Mol Biol Rep, 2022 Jun. PMID 35220512
  4. Bmi1 induction protects hematopoietic stem cells against pronounced long-term hematopoietic stress. Hidalgo I, et al. Exp Hematol, 2022 May. PMID 35192914
  5. Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1. Zhang J, et al. Oxid Med Cell Longev, 2021. PMID 34873428, Free PMC Article

See all (347) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced Epithelial-Mesenchymal Transition.
    Title: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition.
  2. Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
    Title: Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
  3. BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy.
    Title: BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy.
  4. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation.
    Title: BMI1 is required for melanocyte stem cell maintenance and hair pigmentation.
  5. Nuclear translocation of YAP drives BMI-associated hepatocarcinogenesis in hepatitis B virus infection.
    Title: Nuclear translocation of YAP drives BMI-associated hepatocarcinogenesis in hepatitis B virus infection.
  6. BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells.
    Title: BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells.
  7. Therapeutic inhibition of Bmi-1 ablates chemoresistant cancer stem cells in adenoid cystic carcinoma.
    Title: Therapeutic inhibition of Bmi-1 ablates chemoresistant cancer stem cells in adenoid cystic carcinoma.
  8. Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)2 D3 Deficiency and Downregulates GATA4-Dependent Rela Transcription.
    Title: Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
  9. Bmi1 induction protects hematopoietic stem cells against pronounced long-term hematopoietic stress.
    Title: Bmi1 induction protects hematopoietic stem cells against pronounced long-term hematopoietic stress.
  10. The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1.
    Title: The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1.
Submit: New GeneRIF Correction See all GeneRIFs (179)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RING-like zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within humoral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of adaxial/abaxial pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within rostrocaudal neural tube patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polycomb complex protein BMI-1
Names
B lymphoma Mo-MLV insertion region 1
polycomb group RING finger protein 4
polycomb group ring finger 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416911.1 → NP_001403840.1  polycomb complex protein BMI-1

    Status: VALIDATED

    Source sequence(s)
    AL928680
    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58

  2. NM_001416912.1 → NP_001403841.1  polycomb complex protein BMI-1

    Status: VALIDATED

    Source sequence(s)
    AL928680
    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58
    Related
    ENSMUSP00000110300.2, ENSMUST00000051929.13

  3. NM_001416913.1 → NP_001403842.1  polycomb complex protein BMI-1

    Status: VALIDATED

    Source sequence(s)
    AL928680
    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58

  4. NM_001416914.1 → NP_001403843.1  polycomb complex protein BMI-1

    Status: VALIDATED

    Source sequence(s)
    AL928680
    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58

  5. NM_007552.5 → NP_031578.2  polycomb complex protein BMI-1

    See identical proteins and their annotated locations for NP_031578.2

    Status: VALIDATED

    Source sequence(s)
    AL928680
    Consensus CDS
    CCDS15711.1
    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58, Q3ULL2
    Related
    ENSMUSP00000028071.7, ENSMUST00000028071.13
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 132
    rad18; DNA repair protein rad18
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17165
    Location:130 → 224
    RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    18681953..18691440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25916.1 GenPept UniProtKB/Swiss-Prot:P25916

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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