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Arl4a ADP-ribosylation factor-like 4A [ Mus musculus (house mouse) ]

Gene ID: 11861, updated on 11-Apr-2024

Summary

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Official Symbol
Arl4aprovided by MGI
Official Full Name
ADP-ribosylation factor-like 4Aprovided by MGI
Primary source
MGI:MGI:99437
See related
Ensembl:ENSMUSG00000047446 AllianceGenome:MGI:99437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arl4
Summary
Predicted to enable GTP binding activity. Acts upstream of or within brown fat cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; jaw bone; paraxial mesenchyme; skeletal musculature; and testis. Orthologous to human ARL4A (ADP ribosylation factor like GTPase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 30.0), liver E14 (RPKM 10.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 B1; 12 18.06 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40083290..40087986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40033291..40037987, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40399 Neighboring gene ubiquitin specific peptidase 9, X chromosome pseudogene Neighboring gene STARR-seq mESC enhancer starr_31951 Neighboring gene predicted gene, 53717 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40763838-40764139 Neighboring gene STARR-positive B cell enhancer ABC_E7130 Neighboring gene ADP-ribosylation factor-like 4A, opposite strand Neighboring gene scinderin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Schürmann A, et al. Mol Cell Biol, 2002 Apr. PMID 11909968, Free PMC Article
  2. The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell. Jacobs S, et al. Biochem J, 1998 Oct 15. PMID 9761722, Free PMC Article
  3. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. Lin CY, et al. J Biol Chem, 2000 Dec 1. PMID 10980193
  4. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
  5. Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm. Buttitta L, et al. Dev Biol, 2003 Jun 1. PMID 12781685

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
    Title: Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
  2. This gene was a target of WNT signlaing in the dorsal somite.
    Title: Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 4A
Names
ADP-ribosylation factor-like 4
ADP-ribosylation-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039515.1 → NP_001034604.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_001034604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131921, AK048606, CJ164717
    Consensus CDS
    CCDS25890.1
    UniProtKB/Swiss-Prot
    P41275, P61213, Q3TGR5
    Related
    ENSMUSP00000099013.4, ENSMUST00000101472.4
    Conserved Domains (1) summary
    cd04152
    Location:18 → 200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

  2. NM_007487.3 → NP_031513.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_031513.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC131921, AK048606
    Consensus CDS
    CCDS25890.1
    UniProtKB/Swiss-Prot
    P41275, P61213, Q3TGR5
    Related
    ENSMUSP00000114458.2, ENSMUST00000146905.2
    Conserved Domains (1) summary
    cd04152
    Location:18 → 200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40083290..40087986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61213.1 GenPept UniProtKB/Swiss-Prot:P61213

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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