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Birc3 baculoviral IAP repeat-containing 3 [ Mus musculus (house mouse) ]

Gene ID: 11796, updated on 18-Apr-2024

Summary

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Official Symbol
Birc3provided by MGI
Official Full Name
baculoviral IAP repeat-containing 3provided by MGI
Primary source
MGI:MGI:1197007
See related
Ensembl:ENSMUSG00000032000 AllianceGenome:MGI:1197007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of NIK/NF-kappaB signaling. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 15.4), large intestine adult (RPKM 9.0) and 20 other tissues See more
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Genomic context

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Location:
9 A1; 9 2.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7848698..7873199, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7847468..7873205, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 123 Neighboring gene STARR-seq mESC enhancer starr_23223 Neighboring gene microRNA 5618 Neighboring gene STARR-seq mESC enhancer starr_23227 Neighboring gene baculoviral IAP repeat-containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7872853-7873154 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7873159-7873459 Neighboring gene STARR-seq mESC enhancer starr_23228 Neighboring gene STARR-seq mESC enhancer starr_23230 Neighboring gene STARR-seq mESC enhancer starr_23231 Neighboring gene STARR-seq mESC enhancer starr_23234 Neighboring gene yes-associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_23236 Neighboring gene STARR-seq mESC enhancer starr_23238 Neighboring gene STARR-seq mESC enhancer starr_23239 Neighboring gene cilia and flagella associated protein 300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination. Li Y, et al. EMBO Rep, 2023 Feb 6. PMID 36440627, Free PMC Article
  2. Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis. Biswas DD, et al. J Neuroinflammation, 2022 Jun 19. PMID 35718775, Free PMC Article
  3. cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK and NF-κB. Philip L, et al. J Mol Cell Cardiol, 2013 Sep. PMID 23837962
  4. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Mahoney DJ, et al. Proc Natl Acad Sci U S A, 2008 Aug 19. PMID 18697935, Free PMC Article
  5. Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice. Chua CC, et al. Biochim Biophys Acta, 2007 Apr. PMID 17321613, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
    Title: Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
  2. M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.
    Title: M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.
  3. Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis.
    Title: Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis.
  4. A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma.
    Title: A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma.
  5. Targeting cIAPs attenuates CCl4-induced liver fibrosis by increasing MMP9 expression derived from neutrophils.
    Title: Targeting cIAPs attenuates CCl(4)-induced liver fibrosis by increasing MMP9 expression derived from neutrophils.
  6. IAP inhibition or loss of both cIAP2 and XIAP resulted in a strong blockage in autophagic flux and mitophagy, suggesting that XIAP deficiency may also drive Crohn's Disease due to defects in autophagy.
    Title: Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.
  7. Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation.
    Title: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
  8. These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1beta. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations.
    Title: XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
  9. These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase cIAP1.
    Title: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.
  10. Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha.
    Title: IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in necroptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein polyubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
baculoviral IAP repeat-containing protein 3
Names
IAP-1
RING-type E3 ubiquitin transferase BIRC3
apoptosis inhibitor 1
baculoviral IAP repeat-containing 2
cellular inhibitor of apoptosis 2
inhibitor of apoptosis protein 1
mIAP-1
NP_031490.2
XP_006509891.1
XP_006509892.1
XP_006509893.1
XP_006509894.1
XP_011240654.1
XP_011240655.1
XP_036010464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007464.3 → NP_031490.2  baculoviral IAP repeat-containing protein 3

    See identical proteins and their annotated locations for NP_031490.2

    Status: VALIDATED

    Source sequence(s)
    AK162108, CA556605, U88908
    Consensus CDS
    CCDS22812.2
    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    UniProtKB/TrEMBL
    A2CGA5
    Related
    ENSMUSP00000013949.9, ENSMUST00000013949.15
    Conserved Domains (4) summary
    smart00238
    Location:254 → 324
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:440 → 528
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:376 → 425
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:549 → 602
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7848698..7873199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509829.5 → XP_006509892.1  baculoviral IAP repeat-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    Conserved Domains (4) summary
    smart00238
    Location:311 → 381
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:497 → 585
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:433 → 482
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:606 → 659
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

  2. XM_006509828.5 → XP_006509891.1  baculoviral IAP repeat-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    Conserved Domains (4) summary
    smart00238
    Location:333 → 403
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:519 → 607
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:455 → 504
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:628 → 681
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

  3. XM_006509831.5 → XP_006509894.1  baculoviral IAP repeat-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006509894.1

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    UniProtKB/TrEMBL
    A2CGA5
    Conserved Domains (4) summary
    smart00238
    Location:254 → 324
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:440 → 528
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:376 → 425
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:549 → 602
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

  4. XM_011242353.4 → XP_011240655.1  baculoviral IAP repeat-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011240655.1

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    UniProtKB/TrEMBL
    A2CGA5
    Conserved Domains (4) summary
    smart00238
    Location:254 → 324
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:440 → 528
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:376 → 425
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:549 → 602
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

  5. XM_036154571.1 → XP_036010464.1  baculoviral IAP repeat-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    UniProtKB/TrEMBL
    A2CGA5
    Conserved Domains (4) summary
    smart00238
    Location:254 → 324
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:440 → 528
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:376 → 425
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:549 → 602
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

  6. XM_006509830.5 → XP_006509893.1  baculoviral IAP repeat-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006509893.1

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    UniProtKB/TrEMBL
    A2CGA5
    Conserved Domains (4) summary
    smart00238
    Location:254 → 324
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:440 → 528
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:376 → 425
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:549 → 602
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

  7. XM_011242352.4 → XP_011240654.1  baculoviral IAP repeat-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011240654.1

    UniProtKB/Swiss-Prot
    E9QLX3, O08863
    UniProtKB/TrEMBL
    A2CGA5
    Conserved Domains (4) summary
    smart00238
    Location:254 → 324
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:440 → 528
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:376 → 425
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:549 → 602
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08863.2 GenPept UniProtKB/Swiss-Prot:O08863

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