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Ap1m2 adaptor protein complex AP-1, mu 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 11768, updated on 3-Apr-2024

Summary

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Official Symbol
Ap1m2provided by MGI
Official Full Name
adaptor protein complex AP-1, mu 2 subunitprovided by MGI
Primary source
MGI:MGI:1336974
See related
Ensembl:ENSMUSG00000003309 AllianceGenome:MGI:1336974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mu1B; [m]1B; D9Ertd818e
Summary
Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 27.8), colon adult (RPKM 22.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.76 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21206753..21223617, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21294615..21312349, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21125421-21125608 Neighboring gene predicted gene, 39302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21132507-21132711 Neighboring gene solute carrier family 44, member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21136702-21136885 Neighboring gene predicted gene, 36198 Neighboring gene interleukin enhancer binding factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice. Jangid A, et al. PLoS One, 2020. PMID 32208434, Free PMC Article
  2. Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan-based motif. Uwada J, et al. J Cell Sci, 2014 Jul 15. PMID 24829147
  3. AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Hase K, et al. Gastroenterology, 2013 Sep. PMID 23684748
  4. The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice. Takahashi D, et al. Gastroenterology, 2011 Aug. PMID 21669204
  5. The absence of a clathrin adapter confers unique polarity essential to proximal tubule function. Schreiner R, et al. Kidney Int, 2010 Aug. PMID 20531453, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in basolateral protein secretion NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network TAS
Traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
AP-1 complex subunit mu-2
Names
AP-mu chain family member mu1B
adaptor protein complex AP-1 subunit mu-2
adaptor-related protein complex 1 mu-2 subunit
adaptor-related protein complex 1 subunit mu-2
adaptor-related protein complex AP-1, mu 2 subunit
clathrin assembly protein complex 1 medium chain 2
clathrin assembly protein complex 1 mu-2 medium chain 2
golgi adaptor HA1/AP1 adaptin mu-2 subunit
mu-adaptin 2
mu1B-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110300.2 → NP_001103770.1  AP-1 complex subunit mu-2 isoform 1

    See identical proteins and their annotated locations for NP_001103770.1

    Status: VALIDATED

    Source sequence(s)
    AC122525
    Consensus CDS
    CCDS52734.1
    UniProtKB/Swiss-Prot
    Q99LA4, Q9CWP7, Q9WVP1
    UniProtKB/TrEMBL
    A0A0R4J1L4
    Related
    ENSMUSP00000111093.4, ENSMUST00000115433.11
    Conserved Domains (2) summary
    cd14835
    Location:4 → 142
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    cl10970
    Location:154 → 423
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  2. NM_001410422.1 → NP_001397351.1  AP-1 complex subunit mu-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122525

  3. NM_001410423.1 → NP_001397352.1  AP-1 complex subunit mu-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122525

  4. NM_009678.3 → NP_033808.2  AP-1 complex subunit mu-2 isoform 2

    See identical proteins and their annotated locations for NP_033808.2

    Status: VALIDATED

    Source sequence(s)
    AC122525
    Consensus CDS
    CCDS22902.1
    UniProtKB/Swiss-Prot
    Q99LA4, Q9CWP7, Q9WVP1
    UniProtKB/TrEMBL
    A0A0R4IZX6
    Related
    ENSMUSP00000003397.8, ENSMUST00000003397.9
    Conserved Domains (2) summary
    cd14835
    Location:4 → 142
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    cl10970
    Location:154 → 421
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21206753..21223617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVP1.3 GenPept UniProtKB/Swiss-Prot:Q9WVP1

Gene LinkOut

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