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Helb helicase (DNA) B [ Mus musculus (house mouse) ]

Gene ID: 117599, updated on 11-Apr-2024

Summary

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Official Symbol
Helbprovided by MGI
Official Full Name
helicase (DNA) Bprovided by MGI
Primary source
MGI:MGI:2152895
See related
Ensembl:ENSMUSG00000020228 AllianceGenome:MGI:2152895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D10Ertd664e
Summary
Enables DNA helicase activity. Involved in cellular response to DNA damage stimulus; negative regulation of double-strand break repair via homologous recombination; and regulation of DNA double-strand break processing. Acts upstream of or within DNA-dependent DNA replication. Located in cytoplasm and nucleus. Orthologous to human HELB (DNA helicase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 4.4), thymus adult (RPKM 4.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 67.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (119919513..119948917, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120083608..120113010, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_28051 Neighboring gene STARR-seq mESC enhancer starr_28052 Neighboring gene predicted gene, 51815 Neighboring gene glutamate receptor interacting protein 1, opposite strand 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:119501533-119501834 Neighboring gene STARR-seq mESC enhancer starr_28053 Neighboring gene STARR-positive B cell enhancer ABC_E724 Neighboring gene STARR-seq mESC enhancer starr_28054 Neighboring gene STARR-seq mESC enhancer starr_28055 Neighboring gene STARR-seq mESC enhancer starr_28056 Neighboring gene STARR-seq mESC enhancer starr_28058 Neighboring gene STARR-positive B cell enhancer ABC_E9354 Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene predicted gene, 34545 Neighboring gene predicted gene, 40781

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a cDNA encoding mouse DNA helicase B, which has homology to Escherichia coli RecD protein, and identification of a mutation in the DNA helicase B from tsFT848 temperature-sensitive DNA replication mutant cells. Tada S, et al. Nucleic Acids Res, 2001 Sep 15. PMID 11557815, Free PMC Article
  2. HELB Is a Feedback Inhibitor of DNA End Resection. Tkáč J, et al. Mol Cell, 2016 Feb 4. PMID 26774285
  3. Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads. Piprek RP, et al. Reproduction, 2022 Feb 24. PMID 35119382
  4. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA duplex unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication, synthesis of primer ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA replication, synthesis of primer TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA helicase B
NP_536694.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080446.2 → NP_536694.2  DNA helicase B

    See identical proteins and their annotated locations for NP_536694.2

    Status: VALIDATED

    Source sequence(s)
    AB048542, AK131122
    Consensus CDS
    CCDS24203.1
    UniProtKB/Swiss-Prot
    G5E835, Q6KAT5, Q6NVF4, Q8C930, Q9EQT8
    Related
    ENSMUSP00000020449.6, ENSMUST00000020449.12
    Conserved Domains (3) summary
    TIGR01448
    Location:273 → 922
    recD_rel; helicase, putative, RecD/TraA family
    cl21455
    Location:435 → 635
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:855 → 901
    UvrD_C_2; UvrD-like helicase C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    119919513..119948917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004936063.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NVF4.2 GenPept UniProtKB/Swiss-Prot:Q6NVF4

Gene LinkOut

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