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Acsm1 acyl-CoA synthetase medium-chain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 117147, updated on 21-Apr-2024

Summary

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Official Symbol
Acsm1provided by MGI
Official Full Name
acyl-CoA synthetase medium-chain family member 1provided by MGI
Primary source
MGI:MGI:2152200
See related
Ensembl:ENSMUSG00000033533 AllianceGenome:MGI:2152200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Macs; Acas3; Bucs1
Summary
Enables benzoate-CoA ligase activity; butyrate-CoA ligase activity; and decanoate-CoA ligase activity. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in lung and urinary system. Orthologous to human ACSM1 (acyl-CoA synthetase medium chain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 94.8), kidney adult (RPKM 81.4) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 64.02 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119217035..119261738)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119617757..119662515)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene predicted gene, 39078 Neighboring gene predicted gene, 39079 Neighboring gene STARR-seq mESC enhancer starr_20036 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene THUMP domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner. Oka Y, et al. Eur J Biochem, 2003 May. PMID 12709059
  2. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. Fujino T, et al. J Biol Chem, 2001 Sep 21. PMID 11470804
  3. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. Labialle S, et al. EMBO J, 2014 Oct 1. PMID 25124681, Free PMC Article
  4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables benzoate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables benzoate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables butyrate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables butyrate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables butyrate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables decanoate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables decanoate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acyl-coenzyme A synthetase ACSM1, mitochondrial
Names
acetyl-Coenzyme A synthetase 3
benzoate--CoA ligase
butyrate--CoA ligase 1
butyryl Coenzyme A synthetase 1
butyryl-coenzyme A synthetase 1
lipoate-activating enzyme
middle-chain acyl-CoA synthetase 1
NP_001407267.1
NP_001407268.1
NP_473435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420338.1 → NP_001407267.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134587

  2. NM_001420339.1 → NP_001407268.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134587

  3. NM_054094.6 → NP_473435.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_473435.1

    Status: VALIDATED

    Source sequence(s)
    AC134587
    Consensus CDS
    CCDS21783.1
    UniProtKB/Swiss-Prot
    Q3UED4, Q91VA0
    UniProtKB/TrEMBL
    D3Z106
    Related
    ENSMUSP00000036140.7, ENSMUST00000047929.13
    Conserved Domains (1) summary
    cl17068
    Location:42 → 569
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119217035..119261738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VA0.1 GenPept UniProtKB/Swiss-Prot:Q91VA0

Gene LinkOut

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