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NEDD4L NEDD4 like E3 ubiquitin protein ligase [ Trachypithecus francoisi (Francois's langur) ]

Gene ID: 117099196, updated on 19-Mar-2024

Summary

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Gene symbol
NEDD4L
Gene description
NEDD4 like E3 ubiquitin protein ligase
See related
EnsemblRapid:ENSTFRG00000001974
Gene type
protein coding
RefSeq status
MODEL
Organism
Trachypithecus francoisi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Trachypithecus
Orthologs
human mouse all
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Genomic context

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See NEDD4L in Genome Data Viewer
Location:
chromosome: Un
Exon count:
35
Annotation release Status Assembly Chr Location
100 current Tfra_2.0 (GCF_009764315.1) Unplaced Scaffold NW_022681435.1 (3795792..4165738)

NW_022681435.1Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene 28S ribosomal protein S17, mitochondrial-like Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene uncharacterized LOC117098795 Neighboring gene alpha kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_022681435 Unplaced Scaffold Reference Tfra_2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEDD4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Trachypithecus francoisi Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Tfra_2.0 Primary Assembly

Genomic

  1. NW_022681435.1 Reference Tfra_2.0 Primary Assembly

    Range
    3795792..4165738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033238701.1 → XP_033094592.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

    Related
    ENSTFRP00000002621.1, ENSTFRT00000003263.1
    Conserved Domains (5) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:549 → 581
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:642 → 971
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:291 → 502
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:387 → 416
    WW; WW domain

  2. XM_033238705.1 → XP_033094596.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

    Related
    ENSTFRP00000002638.1, ENSTFRT00000003283.1
    Conserved Domains (4) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:529 → 561
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:622 → 951
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:367 → 396
    WW; WW domain

  3. XM_033238697.1 → XP_033094588.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

    Conserved Domains (5) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:549 → 599
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:660 → 989
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:291 → 502
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:387 → 416
    WW; WW domain

  4. XM_033238710.1 → XP_033094601.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

    Conserved Domains (4) summary
    smart00456
    Location:408 → 440
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:501 → 830
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:246 → 275
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  5. XM_033238707.1 → XP_033094598.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

    Conserved Domains (5) summary
    smart00456
    Location:428 → 460
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:521 → 850
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:170 → 381
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:266 → 295
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  6. XM_033238670.1 → XP_033094561.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    Conserved Domains (6) summary
    smart00456
    Location:725 → 775
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:836 → 1165
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:676 → 706
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:478 → 504
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  7. XM_033238690.1 → XP_033094581.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

    Conserved Domains (5) summary
    smart00456
    Location:659 → 709
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:770 → 1099
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00397
    Location:478 → 504
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  8. XM_033238636.1 → XP_033094527.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

    Conserved Domains (7) summary
    smart00456
    Location:829 → 879
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:940 → 1269
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:571 → 782
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:780 → 810
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:667 → 696
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  9. XM_033238653.1 → XP_033094544.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

    Conserved Domains (6) summary
    smart00456
    Location:809 → 859
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:920 → 1249
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:760 → 790
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:647 → 676
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  10. XM_033238682.1 → XP_033094573.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    Conserved Domains (6) summary
    smart00456
    Location:725 → 757
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:818 → 1147
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:676 → 706
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:478 → 504
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  11. XM_033238695.1 → XP_033094586.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

    Conserved Domains (5) summary
    smart00456
    Location:659 → 691
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:752 → 1081
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00397
    Location:478 → 504
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  12. XM_033238643.1 → XP_033094534.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

    Related
    ENSTFRP00000002709.1, ENSTFRT00000003381.1
    Conserved Domains (7) summary
    smart00456
    Location:829 → 861
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:922 → 1251
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:571 → 782
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:780 → 810
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:667 → 696
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain

  13. XM_033238661.1 → XP_033094552.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

    Conserved Domains (6) summary
    smart00456
    Location:809 → 841
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:902 → 1231
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:96 → 328
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:760 → 790
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:647 → 676
    WW; WW domain
    cl14603
    Location:380 → 433
    C2; C2 domain
Nucleotide Protein
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