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Atp5f1c ATP synthase F1 subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 116550, updated on 11-Apr-2024

Summary

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Official Symbol
Atp5f1cprovided by RGD
Official Full Name
ATP synthase F1 subunit gammaprovided by RGD
Primary source
RGD:620011
See related
Ensembl:ENSRNOG00000019223 AllianceGenome:RGD:620011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5c1
Summary
Contributes to ATP hydrolysis activity. Involved in ATP metabolic process and cellular response to nitric oxide. Located in mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Biomarker of schizophrenia. Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 5362.9), Muscle (RPKM 3755.3) and 8 other tissues See more
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Genomic context

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Location:
17q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (73333584..73355872)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (68423927..68446169)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (72209321..72231562)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546431 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene uncharacterized LOC120097843 Neighboring gene GATA binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. Sun L, et al. Brain Res Bull, 2018 Sep. PMID 30142370
  2. Thyroid hormone-related regulation of gene expression in human fatty liver. Pihlajamäki J, et al. J Clin Endocrinol Metab, 2009 Sep. PMID 19549744, Free PMC Article
  3. Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells. Tapia-Limonchi R, et al. Islets, 2014. PMID 25658244, Free PMC Article
  4. The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis. Bianchet MA, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736690, Free PMC Article
  5. Mitochondrial ATP synthase: dramatic Mg2+-induced alterations in the structure and function of the F1-ATPase moiety. Pedersen PL, et al. Biochemistry, 1987 Dec 29. PMID 2894844

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit gamma, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
F-ATPase gamma subunit
NP_446277.1
XP_006254291.1
XP_006254292.1
XP_006254293.1
XP_063132091.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053825.2 → NP_446277.1  ATP synthase subunit gamma, mitochondrial

    See identical proteins and their annotated locations for NP_446277.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059158
    UniProtKB/TrEMBL
    A0A8I5YBP6, F7FFJ9, Q6PCU0
    Conserved Domains (1) summary
    TIGR01146
    Location:26 → 297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    73333584..73355872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276021.1 → XP_063132091.1  ATP synthase subunit gamma, mitochondrial isoform X1

    UniProtKB/TrEMBL
    F7FFJ9, Q6PCU0

  2. XM_006254230.5 → XP_006254292.1  ATP synthase subunit gamma, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_006254292.1

    UniProtKB/TrEMBL
    A0A8I5YBP6, A0A8J8YGG0
    Related
    ENSRNOP00000061946.4
    Conserved Domains (1) summary
    TIGR01146
    Location:26 → 297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

  3. XM_006254229.3 → XP_006254291.1  ATP synthase subunit gamma, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006254291.1

    UniProtKB/TrEMBL
    A0A8I5YBP6, A0A8J8YGG0
    Conserved Domains (1) summary
    TIGR01146
    Location:26 → 297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

  4. XM_006254231.5 → XP_006254293.1  ATP synthase subunit gamma, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    P35435
    Related
    ENSRNOP00000076528.1
    Conserved Domains (1) summary
    TIGR01146
    Location:2 → 273
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35435.2 GenPept UniProtKB/Swiss-Prot:P35435

Gene LinkOut

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