Ager advanced glycosylation end product-specific receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agerprovided by MGI
Official Full Name: advanced glycosylation end product-specific receptorprovided by MGI
Primary source: MGI:MGI:893592
See related: Ensembl:ENSMUSG00000015452 AllianceGenome:MGI:893592
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAGE
Summary: Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward lung adult (RPKM 481.7) See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.18 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34816545..34819911)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34597460..34600937)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression.
Title: Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression.
Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice.
Title: Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice.
HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice.
Title: HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice.
Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia-derived neuroinflammation.
Title: Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia-derived neuroinflammation.
Macrophage RAGE activation is proinflammatory in NASH.
Title: Macrophage RAGE activation is proinflammatory in NASH.
RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation.
Title: RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation.
RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury.
Title: RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury.
Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE.
Title: Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE.
Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.
Title: Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.
RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice.
Title: RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice.

Submit: New GeneRIF Correction See all GeneRIFs (322)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

PMC162222P1 (e-PCR)
- UniSTS:271463

RH126902 (e-PCR)
- UniSTS:209296

RH124616 (e-PCR)
- UniSTS:161438

L33412 (e-PCR)
- UniSTS:124899

Ager (e-PCR), detects polymorphism
- UniSTS:141050

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S100 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables high mobility group box 1 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables laminin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within induction of positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood circulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of monocyte chemotactic protein-1 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of CD4-positive, alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: advanced glycosylation end product-specific receptor

Names: advanced glycation end-products receptor; receptor for advanced glycosylation end products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271422.1 → NP_001258351.1 advanced glycosylation end product-specific receptor isoform b precursor

See identical proteins and their annotated locations for NP_001258351.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AK004802, CT009767

Consensus CDS

CCDS70795.1

UniProtKB/Swiss-Prot

Q62151

Related

ENSMUSP00000134401.2, ENSMUST00000174496.9

Conserved Domains (3) summary

smart00408
Location:249 → 304

IGc2; Immunoglobulin C-2 Type

smart00409
Location:24 → 116

IG; Immunoglobulin

pfam08205
Location:123 → 216

C2-set_2; CD80-like C2-set immunoglobulin domain
NM_001271423.1 → NP_001258352.1 advanced glycosylation end product-specific receptor isoform c precursor

See identical proteins and their annotated locations for NP_001258352.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

CT009767

Consensus CDS

CCDS70796.1

UniProtKB/Swiss-Prot

Q62151

Related

ENSMUSP00000134579.2, ENSMUST00000173992.8

Conserved Domains (3) summary

smart00408
Location:240 → 295

IGc2; Immunoglobulin C-2 Type

smart00410
Location:24 → 107

IG_like; Immunoglobulin like

pfam08205
Location:114 → 207

C2-set_2; CD80-like C2-set immunoglobulin domain
NM_001271424.1 → NP_001258353.1 advanced glycosylation end product-specific receptor isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains multiple differences in the coding region, compared to variant 1, and initiates translation at an alternate start codon. The encodes isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

CT009767

UniProtKB/TrEMBL

F1ABR7

Related

ENSMUST00000184805.8

Conserved Domains (3) summary

smart00410
Location:159 → 235

IG_like; Immunoglobulin like

pfam08205
Location:40 → 133

C2-set_2; CD80-like C2-set immunoglobulin domain

cd00096
Location:56 → 60

Ig; Ig strand B [structural motif]
NM_007425.3 → NP_031451.2 advanced glycosylation end product-specific receptor isoform a precursor

See identical proteins and their annotated locations for NP_031451.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

BC061182, CT009767

Consensus CDS

CCDS28649.1

UniProtKB/Swiss-Prot

C5H3H4, C5H3H5, C5H3H7, C5H3I0, C5H7W3, C5H7W4, C5H7W5, C5H7W6, C5H7W7, C5H7W8, C5H7W9, O35444, Q2PGG1, Q62151, V5R4Y0

UniProtKB/TrEMBL

F1ABS0

Related

ENSMUSP00000015596.4, ENSMUST00000015596.10

Conserved Domains (4) summary

smart00408
Location:249 → 304

IGc2; Immunoglobulin C-2 Type

smart00410
Location:242 → 318

IG_like; Immunoglobulin like

pfam08205
Location:123 → 216

C2-set_2; CD80-like C2-set immunoglobulin domain

cl11960
Location:24 → 110

Ig; Immunoglobulin domain

RNA

NR_073173.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate splicing structure near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CT009767

Related

ENSMUST00000174069.8
NR_073175.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) has an alternate splicing structure near the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CT009767

Related

ENSMUST00000173589.8
NR_073176.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) has an alternate splicing structure near the 5' end, and lacks an exon near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CT009767

Related

ENSMUST00000172932.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34816545..34819911

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523501.4 → XP_006523564.1 advanced glycosylation end product-specific receptor isoform X1

See identical proteins and their annotated locations for XP_006523564.1

UniProtKB/TrEMBL

F1ABR8

Conserved Domains (3) summary

smart00408
Location:249 → 277

IGc2; Immunoglobulin C-2 Type

smart00409
Location:24 → 116

IG; Immunoglobulin

pfam08205
Location:123 → 216

C2-set_2; CD80-like C2-set immunoglobulin domain