Crisp3 cysteine-rich secretory protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crisp3provided by MGI
Official Full Name: cysteine-rich secretory protein 3provided by MGI
Primary source: MGI:MGI:102552
See related: Ensembl:ENSMUSG00000025433 AllianceGenome:MGI:102552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aeg2; CRS3; SGP28; CRISP-3
Summary: Predicted to be located in extracellular region and specific granule. Predicted to be active in extracellular space. Is expressed in sublingual gland and submandibular gland. Orthologous to human CRISP3 (cysteine rich secretory protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 17 B2; 17 19.45 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (40532668..40553179, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (40221777..40242288, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest roles for epithelial and neutrophil-derived CRISP3 in endometrial repair and regeneration
Title: Endometrial CRISP3 is regulated throughout the mouse estrous and human menstrual cycle and facilitates adhesion and proliferation of endometrial epithelial cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490592

42T (e-PCR), detects polymorphism
- UniSTS:140951

8T (e-PCR), detects polymorphism
- UniSTS:140988

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteine-rich secretory protein 3

Names: SCP 2; acidic epididymal glycoprotein 2; sperm-coating glycoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009639.3 → NP_033769.1 cysteine-rich secretory protein 3 precursor

See identical proteins and their annotated locations for NP_033769.1

Status: VALIDATED

Source sequence(s)

CV307357, L05560

Consensus CDS

CCDS28783.1

UniProtKB/Swiss-Prot

A2RTK2, Q03402

Related

ENSMUSP00000026499.6, ENSMUST00000026499.6

Conserved Domains (2) summary

pfam08562
Location:194 → 241

Crisp; Crisp

cl00133
Location:37 → 172

SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...