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araf A-Raf proto-oncogene, serine/threonine kinase [ Gadus morhua (Atlantic cod) ]

Gene ID: 115554515, updated on 17-Mar-2024

Summary

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Gene symbol
araf
Gene description
A-Raf proto-oncogene, serine/threonine kinase
See related
Ensembl:ENSGMOG00000012642
Gene type
protein coding
RefSeq status
MODEL
Organism
Gadus morhua
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 11
Exon count:
18
Annotation release Status Assembly Chr Location
100 current gadMor3.0 (GCF_902167405.1) 11 NC_044058.1 (27602945..27621939)

Chromosome 11 - NC_044058.1Genomic Context describing neighboring genes Neighboring gene RAB, member RAS oncogene family-like 6b Neighboring gene uncharacterized LOC115554539 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 4 Neighboring gene leukocyte surface antigen CD53-like Neighboring gene leukocyte surface antigen CD53-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_044058.1 Chromosome 11 Reference gadMor3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase A-Raf

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gadus morhua Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference gadMor3.0 Primary Assembly

Genomic

  1. NC_044058.1 Reference gadMor3.0 Primary Assembly

    Range
    27602945..27621939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030371293.1 → XP_030227153.1  serine/threonine-protein kinase A-Raf isoform X1

    UniProtKB/TrEMBL
    A0A8C4ZGK9, A0A8C5B244
    Related
    ENSGMOP00000013528.2, ENSGMOT00000013885.2
    Conserved Domains (3) summary
    cd00029
    Location:104 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17133
    Location:24 → 96
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cl21453
    Location:311 → 575
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030371291.1 → XP_030227151.1  serine/threonine-protein kinase A-Raf isoform X1

    UniProtKB/TrEMBL
    A0A8C4ZGK9, A0A8C5B244
    Conserved Domains (3) summary
    cd00029
    Location:104 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17133
    Location:24 → 96
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cl21453
    Location:311 → 575
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030371296.1 → XP_030227156.1  serine/threonine-protein kinase A-Raf isoform X3

    UniProtKB/TrEMBL
    A0A8C5B244
    Related
    ENSGMOP00000038978.1, ENSGMOT00000038041.1
    Conserved Domains (3) summary
    cd00029
    Location:104 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17133
    Location:24 → 96
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cl21453
    Location:277 → 541
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030371295.1 → XP_030227155.1  serine/threonine-protein kinase A-Raf isoform X2

    UniProtKB/TrEMBL
    A0A8C5FEG8
    Related
    ENSGMOP00000036657.1, ENSGMOT00000031529.1
    Conserved Domains (3) summary
    cd00029
    Location:104 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17133
    Location:24 → 96
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cl21453
    Location:311 → 572
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030371292.1 → XP_030227152.1  serine/threonine-protein kinase A-Raf isoform X1

    UniProtKB/TrEMBL
    A0A8C4ZGK9, A0A8C5B244
    Conserved Domains (3) summary
    cd00029
    Location:104 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17133
    Location:24 → 96
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cl21453
    Location:311 → 575
    PKc_like; Protein Kinases, catalytic domain

  6. XM_030371294.1 → XP_030227154.1  serine/threonine-protein kinase A-Raf isoform X1

    UniProtKB/TrEMBL
    A0A8C4ZGK9, A0A8C5B244
    Conserved Domains (3) summary
    cd00029
    Location:104 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17133
    Location:24 → 96
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cl21453
    Location:311 → 575
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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