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Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11529, updated on 11-Apr-2024

Summary

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Official Symbol
Adh7provided by MGI
Official Full Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideprovided by MGI
Primary source
MGI:MGI:87926
See related
Ensembl:ENSMUSG00000055301 AllianceGenome:MGI:87926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adh3; Adh4; Adh-3; Adt-1; Adh-3e; Adh-3t; Adh3-e; Adh3-t
Summary
Enables NAD-retinol dehydrogenase activity and alcohol dehydrogenase (NAD+) activity. Acts upstream of or within ethanol catabolic process; retinoic acid metabolic process; and retinol metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including branchial arch; embryo mesenchyme; endocrine gland; neural fold; and reproductive system. Used to study Parkinson's disease. Orthologous to human ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 7.8), stomach adult (RPKM 6.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 64.13 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137903828..137937803)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138198064..138232042)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09106 Neighboring gene STARR-positive B cell enhancer ABC_E3473 Neighboring gene tRNA methyltransferase 10A Neighboring gene RIKEN cDNA 4930579F01 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:137861123-137861424 Neighboring gene RIKEN cDNA 0610031O16 gene Neighboring gene predicted gene, 40156 Neighboring gene Adh1 promoter region Neighboring gene alcohol dehydrogenase 1 (class I)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice. Yi HS, et al. Hepatology, 2014 Sep. PMID 24668648, Free PMC Article
  2. Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3. Molotkov A, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11959987, Free PMC Article
  3. Gene structure and promoter for Adh3 encoding mouse class IV alcohol dehydrogenase (retinol dehydrogenase). Zgombić-Knight M, et al. Genomics, 1997 Apr 1. PMID 9126489
  4. Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice. Belin AC, et al. Behav Brain Res, 2011 Mar 1. PMID 21075145
  5. Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice. Deltour L, et al. Dev Genet, 1999. PMID 10402668

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADH3 promotes liver fibrosis by enhancing hepatic stellate cell activation and inhibiting natural killer cell activity
    Title: Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice.
  2. Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3
    Title: Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3.
  3. Cellular expression of Adh3 in the GUI tract was studied.
    Title: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.
  4. ADH1 functions as the primary enzyme responsible for efficient oxidative clearance of excess retinol, thus providing protection and increased survival during vitamin A toxicity, ADH3 plays a secondary role
    Title: Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase (NAD+) activity TAS
Traceable Author Statement
more info
 PubMed 
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables ethanol binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables omega-hydroxydecanoate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity TAS
Traceable Author Statement
more info
 PubMed 
enables receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
  
enables retinol binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ethanol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ethanol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid omega-oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinoic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
all-trans-retinol dehydrogenase [NAD(+)] ADH7
Names
ADH-C2
IV ADH
alcohol dehydrogenase 3 complex
alcohol dehydrogenase 3 temporal
alcohol dehydrogenase 4
alcohol dehydrogenase class 4 mu/sigma chain
alcohol dehydrogenase class IV mu/sigma chain
gastric alcohol dehydrogenase
omega-hydroxydecanoate dehydrogenase ADH7
retinol dehydrogenase
NP_033756.2
XP_006500982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009626.4 → NP_033756.2  all-trans-retinol dehydrogenase [NAD(+)] ADH7

    See identical proteins and their annotated locations for NP_033756.2

    Status: VALIDATED

    Source sequence(s)
    AF331802, BQ560660
    Consensus CDS
    CCDS38651.1
    UniProtKB/Swiss-Prot
    Q64437
    UniProtKB/TrEMBL
    Q3UMM7, Q9D748
    Related
    ENSMUSP00000087633.6, ENSMUST00000090171.7
    Conserved Domains (1) summary
    cd08299
    Location:3 → 374
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137903828..137937803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500919.4 → XP_006500982.1  all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1

    See identical proteins and their annotated locations for XP_006500982.1

    UniProtKB/Swiss-Prot
    Q64437
    UniProtKB/TrEMBL
    Q3UMM7, Q9D748
    Conserved Domains (1) summary
    cd08299
    Location:3 → 374
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64437.2 GenPept UniProtKB/Swiss-Prot:Q64437

Gene LinkOut

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