Adcyap1 adenylate cyclase activating polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcyap1provided by MGI
Official Full Name: adenylate cyclase activating polypeptide 1provided by MGI
Primary source: MGI:MGI:105094
See related: Ensembl:ENSMUSG00000024256 AllianceGenome:MGI:105094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PACAP
Summary: This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Expression: Biased expression in CNS E18 (RPKM 2.0), CNS E14 (RPKM 1.8) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E5; 17 60.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (93506448..93513967)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (93198245..93206541)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) of the Bed Nucleus of the Stria Terminalis Mediates Heavy Alcohol Drinking in Mice.
Title: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) of the Bed Nucleus of the Stria Terminalis Mediates Heavy Alcohol Drinking in Mice.
Phospholipase C-epsilon defines a PACAP-stimulated pathway for secretion in the chromaffin cell.
Title: Phospholipase C-ε defines a PACAP-stimulated pathway for secretion in the chromaffin cell.
PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
Title: PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRbeta axis during overnutrition.
Title: PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition.
Brainstem ADCYAP1(+) neurons control multiple aspects of sickness behaviour.
Title: Brainstem ADCYAP1(+) neurons control multiple aspects of sickness behaviour.
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.
Title: PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.
Activation of Lateral Parabrachial Nucleus (LPBn) PACAP-Expressing Projection Neurons to the Bed Nucleus of the Stria Terminalis (BNST) Enhances Anxiety-like Behavior.
Title: Activation of Lateral Parabrachial Nucleus (LPBn) PACAP-Expressing Projection Neurons to the Bed Nucleus of the Stria Terminalis (BNST) Enhances Anxiety-like Behavior.
The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy.
Title: The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy.
PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
Title: PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations.
Title: Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations.

Submit: New GeneRIF Correction See all GeneRIFs (157)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC117582P1 (e-PCR)
- UniSTS:270337

Adcyap1 (e-PCR), detects polymorphism
- UniSTS:545884

D17Mit123 (e-PCR), detects polymorphism
- UniSTS:116680

D17Mit123.2 (e-PCR), detects polymorphism
- UniSTS:127954

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables peptide hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables pituitary adenylate cyclase activating polypeptide activity	IBA Inferred from Biological aspect of Ancestor more info
enables pituitary adenylate cyclase activating polypeptide activity	IDA Inferred from Direct Assay more info	PubMed
enables pituitary adenylate cyclase activating polypeptide activity	ISO Inferred from Sequence Orthology more info
enables pituitary adenylate cyclase-activating polypeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in histamine secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response to non-antigenic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pituitary adenylate cyclase-activating polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001315503.2 → NP_001302432.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AC154798

Consensus CDS

CCDS29029.1

UniProtKB/Swiss-Prot

O70176

UniProtKB/TrEMBL

Q3UYH8, Q8BJT8

Related

ENSMUSP00000157279.2, ENSMUST00000234081.2

Conserved Domains (1) summary

pfam00123
Location:131 → 158

Hormone_2; Peptide hormone
NM_001315504.2 → NP_001302433.1 pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is longer and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154798

UniProtKB/TrEMBL

Q8BJT8

Conserved Domains (1) summary

pfam00123
Location:131 → 157

Hormone_2; Peptide hormone
NM_001409525.1 → NP_001396454.1 pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein

Status: VALIDATED

Source sequence(s)

AC154798
NM_001409527.1 → NP_001396456.1 pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein

Status: VALIDATED

Source sequence(s)

AC154798
NM_001409528.1 → NP_001396457.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

Status: VALIDATED

Source sequence(s)

AC154798

UniProtKB/Swiss-Prot

O70176

UniProtKB/TrEMBL

Q3UYH8
NM_001409530.1 → NP_001396459.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

Status: VALIDATED

Source sequence(s)

AC154798

UniProtKB/Swiss-Prot

O70176

UniProtKB/TrEMBL

Q3UYH8
NM_001409531.1 → NP_001396460.1 pituitary adenylate cyclase-activating polypeptide isoform 4

Status: VALIDATED

Source sequence(s)

AC154798
NM_001409532.1 → NP_001396461.1 pituitary adenylate cyclase-activating polypeptide isoform 5

Status: VALIDATED

Source sequence(s)

AC154798
NM_001412216.1 → NP_001399145.1 pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

Status: VALIDATED

Source sequence(s)

AC154798
NM_009625.4 → NP_033755.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

See identical proteins and their annotated locations for NP_033755.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AC154798

Consensus CDS

CCDS29029.1

UniProtKB/Swiss-Prot

O70176

UniProtKB/TrEMBL

Q3UYH8, Q8BJT8

Related

ENSMUSP00000067057.7, ENSMUST00000064775.8

Conserved Domains (1) summary

pfam00123
Location:131 → 158

Hormone_2; Peptide hormone