Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts1provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 1provided by MGI
Primary source: MGI:MGI:109249
See related: Ensembl:ENSMUSG00000022893 AllianceGenome:MGI:109249
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
Expression: Broad expression in lung adult (RPKM 22.1), subcutaneous fat pad adult (RPKM 15.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 48.2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (85590715..85600001, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (85793827..85803113, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity.
Title: The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity.
MYH9 facilitates autoregulation of adipose tissue depot development.
Title: MYH9 facilitates autoregulation of adipose tissue depot development.
An anti-ADAMTS1 treatment relieved muscle dysfunction and fibrosis in dystrophic mice.
Title: An anti-ADAMTS1 treatment relieved muscle dysfunction and fibrosis in dystrophic mice.
ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes.
Title: ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes.
These results confirmed a pro-inflammatory landscape in the absence of ADAMTS1, correlating with tumour blockade, supporting its novel role as a modulator of the immune cell response.
Title: ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response.
The developmental arrest of early secondary follicles following furin disruption might be rooted in the loss of the mature form of ADAMTS1 and compromised proliferation of granulosa cells in mutant mice.
Title: Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Data show that NOTCH1 is a target of ADAMTS1 metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation.
Title: Macrophage-released ADAMTS1 promotes muscle stem cell activation.
Reduced tumors in ADAMTS1 knockout mice displayed a paradoxical increase in vascular density and vascular-related genes; a detailed characterization revealed an impaired vasculature, along with a minor infiltration of macrophages. melanoma xenografts showed a relevant induction of its expression in stroma compartments.
Title: Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis.
Adamts1 acts as an extracellular matrix 'modifier', with miR-181d-induced downregulation, that regulates adipocyte lineage commitment and obesity.
Title: The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling.
Genetic haploinsufficiency of Adamts1 in mice causes thoracic aortic aneurysms and dissections similar to Marfan syndrome.
Title: Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Mit152 (e-PCR), detects polymorphism
- UniSTS:127786

AB001735 (e-PCR)
- UniSTS:160588

NoName (e-PCR)
- UniSTS:548430

A005R14 (e-PCR)
- UniSTS:61779

Adamts1 (e-PCR), detects polymorphism
- UniSTS:532638

Adamts1 (e-PCR), detects polymorphism
- UniSTS:259032

Adamts1 (e-PCR), detects polymorphism
- UniSTS:259581

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within ovulation from ovarian follicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 1

Names: ADAM-TS 1; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1

NP_033751.3

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009621.5 → NP_033751.3 A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

See identical proteins and their annotated locations for NP_033751.3

Status: REVIEWED

Source sequence(s)

AC126936, AK161409, AK163622, BP764139, CF738767

Consensus CDS

CCDS28287.1

UniProtKB/Swiss-Prot

E9QMN9, O54768, P97857

UniProtKB/TrEMBL

Q3U0I4

Related

ENSMUSP00000023610.9, ENSMUST00000023610.15

Conserved Domains (6) summary

smart00209
Location:563 → 615

TSP1; Thrombospondin type 1 repeats

cd04273
Location:259 → 464

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:259 → 468

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:70 → 194

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:726 → 843

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:469 → 549

ADAM_CR; ADAM cysteine-rich