Kiss1r KISS1 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kiss1rprovided by MGI
Official Full Name: KISS1 receptorprovided by MGI
Primary source: MGI:MGI:2148793
See related: Ensembl:ENSMUSG00000035773 AllianceGenome:MGI:2148793
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr54; KiSS-1; kiSS-1R
Summary: Enables G protein-coupled peptide receptor activity. Acts upstream of or within negative regulation of cell migration; negative regulation of cell population proliferation; and signal transduction. Located in cell surface. Is expressed in alimentary system; brain; genitourinary system; sensory organ; and thymus. Used to study hypogonadotropic hypogonadism 8 with or without anosmia. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 3.2), adrenal adult (RPKM 2.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79752786..79759922)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79916952..79924088)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uterine kisspeptin receptor critically regulates epithelial estrogen receptor alpha transcriptional activity at the time of embryo implantation in a mouse model.
Title: Uterine kisspeptin receptor critically regulates epithelial estrogen receptor α transcriptional activity at the time of embryo implantation in a mouse model.
KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a highglucose environment.
Title: KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment.
These findings suggest that the previously observed obesity and decreased metabolism in global Kiss1r KOs reflect impaired kisspeptin signaling in non-BAT tissues.
Title: Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weight.
Loss of Kiss1r expression is associated with hypogonadal, obese, and metabolically-impaired phenotype.
Title: Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype.
deletion from all cells but GnRH neurons abolishes the effect of kisspeptin on prolactin secretion
Title: Kisspeptin Stimulation of Prolactin Secretion Requires Kiss1 Receptor but Not in Tuberoinfundibular Dopaminergic Neurons.
we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent.
Title: NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice.
These lines of evidence suggest that downregulation of Ob-R and kisspeptin/GPR54 in the murine hypothalamus may contribute to male hypogonadism caused by high-fat diet-induced obesity.
Title: Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity.
G-protein coupled receptor 54 (GPR54) deficiency leads to elevated experimental autoimmune encephalomyelitis (EAE) disease severity independent of the reproductive axis. GPR54 deficiency leads to impaired immunotolerance in association with reduced number of Regulatory T-Lymphocytes, increased T-cell activation, and altered thymocyte subsets.
Title: GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice.
while uterine growth was fully rescued by E2 treatment of Kiss1(-/-) mice and by genetic restoration of kisspeptin signaling in GnRH neurons in Kiss1r(-/-) mice, functional adenogenesis was only marginally restored. Thus, while uterine growth is largely dependent on ovarian E2-output via central kisspeptin signaling, peripheral kisspeptin signaling is indispensable for endometrial adenogenesis and function
Title: Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function.
Study found unaltered hypothalamic metabolic gene expression in Kiss1 receptor knockout mice despite obesity and reduced energy expenditure.
Title: Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (10) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Kiss1r (e-PCR), detects polymorphism
- UniSTS:547516

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell migration	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: kiSS-1 receptor

Names: G-protein coupled receptor 54; G-protein coupled receptor OT7T175; kisspeptins receptor; metastin receptor; orphan G protein-coupled receptor 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359010.1 → NP_001345939.1 kiSS-1 receptor isoform 2

Status: VALIDATED

Source sequence(s)

AC151846, AK039628, AK139303, BE949364

Conserved Domains (2) summary

cd15095
Location:72 → 95

7tmA_KiSS1R; TM helix 5 [structural motif]

cl28897
Location:38 → 204

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_053244.5 → NP_444474.1 kiSS-1 receptor isoform 1

See identical proteins and their annotated locations for NP_444474.1

Status: VALIDATED

Source sequence(s)

AC151846, AK039628, AK139303

Consensus CDS

CCDS23998.1

UniProtKB/Swiss-Prot

Q8K3P2, Q91V45

UniProtKB/TrEMBL

B2CP05, B2CP06

Related

ENSMUSP00000040516.3, ENSMUST00000045529.3

Conserved Domains (1) summary

cd15095
Location:43 → 334

7tmA_KiSS1R; KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79752786..79759922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513076.5 → XP_006513139.1 kiSS-1 receptor isoform X1

See identical proteins and their annotated locations for XP_006513139.1

UniProtKB/Swiss-Prot

Q8K3P2, Q91V45

UniProtKB/TrEMBL

B2CP05, B2CP06

Conserved Domains (1) summary

cd15095
Location:43 → 334

7tmA_KiSS1R; KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006513077.5 → XP_006513140.1 kiSS-1 receptor isoform X1

See identical proteins and their annotated locations for XP_006513140.1

UniProtKB/Swiss-Prot

Q8K3P2, Q91V45

UniProtKB/TrEMBL

B2CP05, B2CP06

Conserved Domains (1) summary

cd15095
Location:43 → 334

7tmA_KiSS1R; KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006513079.5 → XP_006513142.1 kiSS-1 receptor isoform X2

See identical proteins and their annotated locations for XP_006513142.1

UniProtKB/TrEMBL

C5H7S2

Related

ENSMUSP00000151936.2, ENSMUST00000219745.2

Conserved Domains (2) summary

cd14964
Location:45 → 69

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:43 → 172

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily