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Asic2 acid-sensing ion channel 2 [ Mus musculus (house mouse) ]

Gene ID: 11418, updated on 21-Apr-2024

Summary

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Official Symbol
Asic2provided by MGI
Official Full Name
acid-sensing ion channel 2provided by MGI
Primary source
MGI:MGI:1100867
See related
Ensembl:ENSMUSG00000020704 AllianceGenome:MGI:1100867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BNC1; Mdeg; ACIC2; Accn1; BNaC1; BNaC1a
Summary
Enables ion gated channel activity and ligand-gated sodium channel activity. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.0), ovary adult (RPKM 9.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 48.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80770989..81859222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80880163..81968396, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930507D10 gene Neighboring gene sperm acrosome associated 3 Neighboring gene predicted gene, 51909 Neighboring gene STARR-seq mESC enhancer starr_30154 Neighboring gene predicted gene 11416 Neighboring gene STARR-seq mESC enhancer starr_30155 Neighboring gene STARR-seq mESC enhancer starr_30156 Neighboring gene STARR-seq mESC enhancer starr_30157 Neighboring gene STARR-seq mESC enhancer starr_30158 Neighboring gene predicted gene, 51910 Neighboring gene predicted gene, 42084 Neighboring gene STARR-seq mESC enhancer starr_30159 Neighboring gene STARR-seq mESC enhancer starr_30160 Neighboring gene STARR-seq mESC enhancer starr_30161 Neighboring gene RIKEN cDNA 1700071K01 gene Neighboring gene predicted gene 11418 Neighboring gene STARR-seq mESC enhancer starr_30167 Neighboring gene STARR-seq mESC enhancer starr_30168 Neighboring gene STARR-seq mESC enhancer starr_30169 Neighboring gene RIKEN cDNA 5530401A14 gene Neighboring gene predicted gene, 46254 Neighboring gene STARR-seq mESC enhancer starr_30170 Neighboring gene predicted gene 11419 Neighboring gene predicted gene, 31522 Neighboring gene C-C motif chemokine ligand 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension. Detweiler ND, et al. J Appl Physiol (1985), 2019 Aug 1. PMID 31169471, Free PMC Article
  2. Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus. Lee JS, et al. J Gen Physiol, 2019 Jul 1. PMID 31010811, Free PMC Article
  3. Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury. Jiang N, et al. J Cereb Blood Flow Metab, 2017 Feb. PMID 26861816, Free PMC Article
  4. Two di-leucine motifs regulate trafficking and function of mouse ASIC2a. Wu J, et al. Mol Brain, 2016 Jan 27. PMID 26819004, Free PMC Article
  5. Altered myogenic vasoconstriction and regulation of whole kidney blood flow in the ASIC2 knockout mouse. Gannon KP, et al. Am J Physiol Renal Physiol, 2015 Feb 15. PMID 25520010, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
    Title: The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
  2. Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.
    Title: Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.
  3. Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension.
    Title: Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension.
  4. Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus.
    Title: Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus.
  5. Findings suggest a potential role of ASIC 2 in the pathophysiology of multiple sclerosis.
    Title: Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis.
  6. ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells.
    Title: Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells.
  7. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
    Title: Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke.
  8. ASIC2 deletion significantly protected the mouse brain from ischemic damage in vivo.
    Title: Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury.
  9. Studies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
    Title: The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.
  10. differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b, was investigated.
    Title: ASIC subunit ratio and differential surface trafficking in the brain.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated sodium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion-gated channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sour taste ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acid-sensing ion channel 2
Names
acid-sensing (proton-gated) ion channel 2
amiloride-sensitive brain sodium channel
amiloride-sensitive cation channel 1, neuronal (degenerin)
brain sodium channel 1
degenerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034013.2 → NP_001029185.1  acid-sensing ion channel 2 isoform MDEG1

    See identical proteins and their annotated locations for NP_001029185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (MDEG1) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant MDEG2. The resulting isoform (MDEG1) is shorter and has a distinct N-terminus, compared to isoform MDEG2.
    Source sequence(s)
    AK134778, AL645842
    Consensus CDS
    CCDS36243.1
    UniProtKB/Swiss-Prot
    Q5SUU2, Q61203, Q925H0
    UniProtKB/TrEMBL
    Q3UYD3
    Related
    ENSMUSP00000067095.7, ENSMUST00000066197.7
    Conserved Domains (1) summary
    cl02990
    Location:18 → 506
    ASC; Amiloride-sensitive sodium channel

  2. NM_007384.3 → NP_031410.1  acid-sensing ion channel 2 isoform MDEG2

    See identical proteins and their annotated locations for NP_031410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (MDEG2) is the longer transcript and encodes the longer isoform (MDEG2).
    Source sequence(s)
    AL645626, BB342826, BC138530, CJ282964
    Consensus CDS
    CCDS25137.1
    UniProtKB/TrEMBL
    B2RRQ1
    Related
    ENSMUSP00000021045.7, ENSMUST00000021045.13
    Conserved Domains (1) summary
    TIGR00859
    Location:64 → 557
    ENaC; sodium channel transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80770989..81859222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531996.5 → XP_006532059.1  acid-sensing ion channel 2 isoform X1

    Conserved Domains (1) summary
    cl02990
    Location:64 → 590
    ASC; Amiloride-sensitive sodium channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925H0.1 GenPept UniProtKB/Swiss-Prot:Q925H0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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