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Copb1 COPI coat complex subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114023, updated on 5-Mar-2024

Summary

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Official Symbol
Copb1provided by RGD
Official Full Name
COPI coat complex subunit beta 1provided by RGD
Primary source
RGD:620861
See related
Ensembl:ENSRNOG00000057623 AllianceGenome:RGD:620861
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Located in Golgi apparatus and Golgi-associated vesicle. Part of COPI vesicle coat. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 365.1), Adrenal (RPKM 335.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q34
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (177838751..177876688, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (168404334..168438589, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (183695480..183729569, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14, pseudogene 6 Neighboring gene ribosomal protein S18-like 4 Neighboring gene uncharacterized LOC134485165 Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene ATP synthase membrane subunit j, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Zhao L, et al. Proc Natl Acad Sci U S A, 1997 Apr 29. PMID 9114004, Free PMC Article
  2. Beta-COP is essential for transport of protein from the endoplasmic reticulum to the Golgi in vitro. Peter F, et al. J Cell Biol, 1993 Sep. PMID 8376457, Free PMC Article
  3. Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes. Huang X, et al. J Cell Sci, 2004 Apr 15. PMID 15039458
  4. Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Duden R, et al. Cell, 1991 Feb 8. PMID 1840503
  5. The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells. Ceriani M, et al. Exp Cell Res, 2015 Apr 10. PMID 25662281

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A(1)R stimulation of the heart is associated with PLC-initiated PKC-epsilon translocation and association with RACK2
    Title: Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.
  2. RACK2 plays a role in epsilon-PKC anchoring in cardiac myofilaments.
    Title: Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
located_in COPI-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit beta
Names
beta-COP
beta-coat protein
coatomer protein complex, subunit beta 1
receptor for activated C-kinase-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080781.2 → NP_542959.1  coatomer subunit beta

    See identical proteins and their annotated locations for NP_542959.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061882
    UniProtKB/Swiss-Prot
    P23514
    UniProtKB/TrEMBL
    A6I896, A6I897
    Related
    ENSRNOP00000072797.1, ENSRNOT00000083293.2
    Conserved Domains (4) summary
    sd00044
    Location:137 → 161
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:18 → 550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667 → 807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:813 → 944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    177838751..177876688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759660.3 → XP_008757882.1  coatomer subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008757882.1

    UniProtKB/Swiss-Prot
    P23514
    UniProtKB/TrEMBL
    A6I896, A6I897
    Conserved Domains (4) summary
    sd00044
    Location:137 → 161
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:18 → 550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667 → 807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:813 → 944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform

  2. XM_008759661.4 → XP_008757883.1  coatomer subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008757883.1

    UniProtKB/Swiss-Prot
    P23514
    UniProtKB/TrEMBL
    A6I896, A6I897
    Conserved Domains (4) summary
    sd00044
    Location:137 → 161
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:18 → 550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667 → 807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:813 → 944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23514.1 GenPept UniProtKB/Swiss-Prot:P23514

Gene LinkOut

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