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APP amyloid beta precursor protein [ Pseudonaja textilis ]

Gene ID: 113436300, updated on 15-Mar-2024

Summary

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Gene symbol
APP
Gene description
amyloid beta precursor protein
See related
Ensembl:ENSPTXG00000004270
Gene type
protein coding
RefSeq status
MODEL
Organism
Pseudonaja textilis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Acanthophiinae; Pseudonaja
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
17
Annotation release Status Assembly Chr Location
100 current EBS10Xv2-PRI (GCF_900518735.1) Unplaced Scaffold NW_020769322.1 (4984951..5082107)

NW_020769322.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 Neighboring gene uncharacterized protein K02A2.6-like Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene ATP synthase peripheral stalk subunit F6

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020769322 Unplaced Scaffold Reference EBS10Xv2-PRI

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Venomics of the Australian eastern brown snake (Pseudonaja textilis): Detection of new venom proteins and splicing variants. Viala VL, et al. Toxicon, 2015 Dec 1. PMID 26079951

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amyloid-beta A4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Pseudonaja textilis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EBS10Xv2-PRI

Genomic

  1. NW_020769322.1 Reference EBS10Xv2-PRI

    Range
    4984951..5082107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026700637.1 → XP_026556422.1  amyloid-beta A4 protein isoform X2

    UniProtKB/TrEMBL
    A0A670Y238
    Related
    ENSPTXP00000005866.1, ENSPTXT00000006055.1
    Conserved Domains (5) summary
    smart00006
    Location:25 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:639 → 676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:679 → 729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:347 → 529
    APP_E2; E2 domain of amyloid precursor protein

  2. XM_026700635.1 → XP_026556420.1  amyloid-beta A4 protein isoform X1

    UniProtKB/TrEMBL
    A0A670Y905
    Related
    ENSPTXP00000005862.1, ENSPTXT00000006051.1
    Conserved Domains (5) summary
    smart00006
    Location:25 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:657 → 694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:697 → 747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:347 → 529
    APP_E2; E2 domain of amyloid precursor protein
Nucleotide Protein
Heading Accession and Version

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