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Abi1 abl interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 11308, updated on 21-Apr-2024

Summary

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Official Symbol
Abi1provided by MGI
Official Full Name
abl interactor 1provided by MGI
Primary source
MGI:MGI:104913
See related
Ensembl:ENSMUSG00000058835 AllianceGenome:MGI:104913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E3B1; NAP1; abi-1; Ssh3bp1
Summary
Enables protein tyrosine kinase activator activity and signaling adaptor activity. Acts upstream of or within megakaryocyte development; plasma membrane bounded cell projection morphogenesis; and somitogenesis. Located in lamellipodium and neuron projection. Part of SCAR complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 20.0), cortex adult (RPKM 19.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 15.18 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22830085..22930207, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22940073..23040241, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family B member 1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_03920 Neighboring gene STARR-seq mESC enhancer starr_03922 Neighboring gene predicted gene, 52503 Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03923 Neighboring gene STARR-positive B cell enhancer mm9_chr2:22895642-22895943 Neighboring gene STARR-positive B cell enhancer mm9_chr2:22896813-22897114 Neighboring gene predicted gene, 52502 Neighboring gene STARR-seq mESC enhancer starr_03925 Neighboring gene STARR-positive B cell enhancer ABC_E2030 Neighboring gene STARR-positive B cell enhancer ABC_E3360 Neighboring gene acyl-Coenzyme A binding domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E2602 Neighboring gene microtubule associated serine/threonine kinase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice. Xiong X, et al. Oncogenesis, 2012 Sep 3. PMID 23552839, Free PMC Article
  2. Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. Chen S, et al. J Mol Biol, 2008 Nov 7. PMID 18775435, Free PMC Article
  3. Inhibition of v-Abl transformation in 3T3 cells overexpressing different forms of the Abelson interactor protein Abi-1. Ikeguchi A, et al. Oncogene, 2001 Aug 16. PMID 11526477
  4. t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines. Shibuya N, et al. Genes Chromosomes Cancer, 2001 Sep. PMID 11477655
  5. The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling. Cohen J, et al. J Cell Biol, 2019 Apr 1. PMID 30867227, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR/CAS9-mediated knockout of Abi1 inhibits p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways.
    Title: CRISPR/CAS9-mediated knockout of Abi1 inhibits p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways.
  2. Wave complex proteins ABI1 and Wave2 have key roles in regulating signals that control epidermal shape and growth by suppressing Wnt-Sox9 signaling.
    Title: The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
  3. This study shows that bone marrow-specific deletion of Abi1 in a novel mouse model leads to development of an myeloproliferative neoplasms-like phenotype resembling human primary myelofibrosis. Abi1 loss resulted in a significant increase in the activity of the Src family kinases (SFKs), STAT3, and NF-kappaB signaling.
    Title: Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis.
  4. The expression of NESH/Abi-3 caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3-based WAVE2 complex.
    Title: The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.
  5. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis
    Title: CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.
  6. sential role for Abi1 in embryonic survival and WAVE2 complex integrity
    Title: Essential role for Abi1 in embryonic survival and WAVE2 complex integrity.
  7. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
    Title: Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
  8. These results show that the interaction between Abi-1 and betaPIX is involved in the formation of growth factor-induced membrane dorsal ruffles.
    Title: A new interaction between Abi-1 and betaPIX involved in PDGF-activated actin cytoskeleton reorganisation.
  9. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading.
    Title: The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.
  10. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins
    Title: Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6064

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dendrite morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
abl interactor 1
Names
abelson interactor 1
ablphilin-1
eps8 SH3 domain-binding protein
eps8 binding protein
spectrin SH3 domain binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077190.4 → NP_001070658.1  abl interactor 1 isoform 1

    See identical proteins and their annotated locations for NP_001070658.1

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS38061.1
    UniProtKB/Swiss-Prot
    Q3U8V0, Q60747, Q8CBW3, Q91ZM5, Q923I9, Q99KH4
    UniProtKB/TrEMBL
    J3QNK8
    Related
    ENSMUSP00000118491.2, ENSMUST00000123948.8
    Conserved Domains (2) summary
    cd11971
    Location:423 → 481
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  2. NM_001077192.4 → NP_001070660.1  abl interactor 1 isoform 4

    See identical proteins and their annotated locations for NP_001070660.1

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS38060.1
    UniProtKB/TrEMBL
    Q3TMI0, Q3TPY5, Q3UAH6
    Related
    ENSMUSP00000120621.2, ENSMUST00000149719.8
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 164
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:388 → 446
    SH3; Src Homology 3 domain superfamily

  3. NM_001077193.4 → NP_001070661.1  abl interactor 1 isoform 5

    See identical proteins and their annotated locations for NP_001070661.1

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS38058.1
    UniProtKB/TrEMBL
    Q3TMI0, Q3UAH6
    Related
    ENSMUSP00000110191.4, ENSMUST00000114544.10
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 154
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:330 → 388
    SH3; Src Homology 3 domain superfamily

  4. NM_001331043.2 → NP_001317972.1  abl interactor 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS84480.1
    UniProtKB/TrEMBL
    B7ZCU0, J3QNK8
    Related
    ENSMUSP00000088957.7, ENSMUST00000091394.13

  5. NM_001331044.2 → NP_001317973.1  abl interactor 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS84481.1
    UniProtKB/TrEMBL
    B7ZCU3, Q3TMI0, Q3UAH6
    Related
    ENSMUSP00000077997.8, ENSMUST00000078977.14

  6. NM_001331045.2 → NP_001317974.1  abl interactor 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS84479.1
    UniProtKB/TrEMBL
    B7ZCU4, Q3TMI0, Q3UAH6
    Related
    ENSMUSP00000090860.7, ENSMUST00000093171.13

  7. NM_001377510.2 → NP_001364439.1  abl interactor 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    UniProtKB/TrEMBL
    Q3TMI0, Q3UAH6
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 154
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:389 → 447
    SH3; Src Homology 3 domain superfamily

  8. NM_001377511.2 → NP_001364440.1  abl interactor 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    UniProtKB/TrEMBL
    Q3UBL3
    Conserved Domains (1) summary
    cl17036
    Location:209 → 267
    SH3; Src Homology 3 domain superfamily

  9. NM_001377512.2 → NP_001364441.1  abl interactor 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    UniProtKB/TrEMBL
    Q3UBL3
    Conserved Domains (2) summary
    pfam07815
    Location:1 → 27
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:206 → 264
    SH3; Src Homology 3 domain superfamily

  10. NM_001377513.2 → NP_001364442.1  abl interactor 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Conserved Domains (1) summary
    cl17036
    Location:162 → 220
    SH3; Src Homology 3 domain superfamily

  11. NM_001416851.1 → NP_001403780.1  abl interactor 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  12. NM_001416852.1 → NP_001403781.1  abl interactor 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    UniProtKB/TrEMBL
    B7ZCU5
    Related
    ENSMUSP00000116093.2, ENSMUST00000139038.8

  13. NM_001416853.1 → NP_001403782.1  abl interactor 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  14. NM_001416854.1 → NP_001403783.1  abl interactor 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  15. NM_001416855.1 → NP_001403784.1  abl interactor 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  16. NM_001416856.1 → NP_001403785.1  abl interactor 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  17. NM_001416857.1 → NP_001403786.1  abl interactor 1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  18. NM_001416858.1 → NP_001403787.1  abl interactor 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  19. NM_001416859.1 → NP_001403788.1  abl interactor 1 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    UniProtKB/TrEMBL
    B7ZCU2
    Related
    ENSMUSP00000120769.2, ENSMUST00000153931.8

  20. NM_001416860.1 → NP_001403789.1  abl interactor 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  21. NM_001416861.1 → NP_001403790.1  abl interactor 1 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  22. NM_001416862.1 → NP_001403791.1  abl interactor 1 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  23. NM_001416863.1 → NP_001403792.1  abl interactor 1 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  24. NM_001416864.1 → NP_001403793.1  abl interactor 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  25. NM_001416865.1 → NP_001403794.1  abl interactor 1 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  26. NM_001416866.1 → NP_001403795.1  abl interactor 1 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013

  27. NM_007380.5 → NP_031406.2  abl interactor 1 isoform 3

    See identical proteins and their annotated locations for NP_031406.2

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS50513.1
    UniProtKB/TrEMBL
    J3QNK8, Q3TJR5
    Related
    ENSMUSP00000120462.2, ENSMUST00000140164.8
    Conserved Domains (2) summary
    cd11971
    Location:417 → 475
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 164
    Abi_HHR; Abl-interactor HHR

  28. NM_145994.4 → NP_666106.1  abl interactor 1 isoform 2

    See identical proteins and their annotated locations for NP_666106.1

    Status: VALIDATED

    Source sequence(s)
    AL845257, CT030013
    Consensus CDS
    CCDS38059.1
    UniProtKB/TrEMBL
    J3QNK8, Q3TJ64
    Related
    ENSMUSP00000117335.2, ENSMUST00000126112.8
    Conserved Domains (2) summary
    cd11971
    Location:418 → 476
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 164
    Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    22830085..22930207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBW3.3 GenPept UniProtKB/Swiss-Prot:Q8CBW3

Gene LinkOut

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