Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc9a4provided by MGI
Official Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4provided by MGI
Primary source: MGI:MGI:105074
See related: Ensembl:ENSMUSG00000026065 AllianceGenome:MGI:105074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NHE4; D730009J23Rik
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Acts upstream of or within epithelial cell development and gastric acid secretion. Predicted to be located in cytoplasmic vesicle and vacuolar membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and thymus. Orthologous to human SLC9A4 (solute carrier family 9 member A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 9.5), bladder adult (RPKM 2.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 19.51 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40619146..40670188)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40579986..40630731)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake.
Title: SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake.
Disruption of murine NHE4 leads to metabolic acidosis with inappropriate urinary ammonia excretion and decreases the ability of the thick ascending limb to absorb ammonia and to build the corticopapillary ammonia gradient.
Title: More actors in ammonia absorption by the thick ascending limb.
Dra is the major Cl(-)/HCO(3)(-) exchanger coupled with Nhe3 for electroneutral NaCl absorption across mammalian small intestine.
Title: Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.
the mRNAs of different NHE isoforms as well as their subcellular localization (apical versus basolateral) and functional activity were investigated in mouse endometrial epithelial cells
Title: Expression, immunolocalization, and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium.
NHE4, which may normally be coupled with the AE2 Cl-/HCO3- exchanger, is important for normal levels of gastric acid secretion, gastric epithelial cell differentiation, and development of secretory canalicular and tubulovesicular membranes
Title: Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc9a4 (e-PCR), detects polymorphism
- UniSTS:144437

AW990558 (e-PCR)
- UniSTS:185436

D9Mco26 (e-PCR)
- UniSTS:518556

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glandular epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transepithelial ammonium transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 4

Names: NHE-4; Na(+)/H(+) exchanger 4; solute carrier family 9 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177084.4 → NP_796058.1 sodium/hydrogen exchanger 4 precursor

See identical proteins and their annotated locations for NP_796058.1

Status: VALIDATED

Source sequence(s)

AC138210

Consensus CDS

CCDS14913.1

UniProtKB/Swiss-Prot

Q3TCU9, Q8BUE1, Q9WUJ6

Related

ENSMUSP00000027233.8, ENSMUST00000027233.9

Conserved Domains (3) summary

TIGR00840
Location:63 → 621

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:73 → 476

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:569 → 667

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

40619146..40670188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495625.3 → XP_006495688.1 sodium/hydrogen exchanger 4 isoform X1

Conserved Domains (1) summary

TIGR00840
Location:63 → 514

b_cpa1; sodium/hydrogen exchanger 3
XM_006495626.4 → XP_006495689.1 sodium/hydrogen exchanger 4 isoform X2

Conserved Domains (1) summary

TIGR00840
Location:63 → 621

b_cpa1; sodium/hydrogen exchanger 3
XM_036153266.1 → XP_036009159.1 sodium/hydrogen exchanger 4 isoform X3

Conserved Domains (1) summary

TIGR00840
Location:63 → 399

b_cpa1; sodium/hydrogen exchanger 3