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LOC110596868 Cyp7a1 promoter [ Mus musculus (house mouse) ]

Gene ID: 110596868, updated on 15-Mar-2024

Summary

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Gene symbol
LOC110596868
Gene description
Cyp7a1 promoter
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This region represents the promoter of the cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1) gene. This sequence is regulated by binding of peroxisome proliferator activated receptor alpha, nuclear receptor subfamily 1 group H member 3, and one cut homeobox 1 to discrete sites in this region. [provided by RefSeq, Jun 2017]
Orthologs
human all
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Genomic context

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Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (6275600..6275950)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (6275600..6275950)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ras suppressor protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09476 Neighboring gene STARR-positive B cell enhancer ABC_E3480 Neighboring gene UBX domain protein 2B Neighboring gene STARR-seq mESC enhancer starr_09478 Neighboring gene STARR-seq mESC enhancer starr_09479 Neighboring gene cytochrome P450, family 7, subfamily a, polypeptide 1 Neighboring gene RIKEN cDNA 4930430E12 gene Neighboring gene syndecan binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction. Wang M, et al. Hepatology, 2004 Sep. PMID 15349898
  2. Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression. Zhang Y, et al. Biochem J, 2015 Sep 1. PMID 26348907, Free PMC Article
  3. Two uniquely arranged thyroid hormone response elements in the far upstream 5' flanking region confer direct thyroid hormone regulation to the murine cholesterol 7alpha hydroxylase gene. Shin DJ, et al. Nucleic Acids Res, 2006. PMID 16899449, Free PMC Article
  4. The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer. Gbaguidi GF, et al. Nucleic Acids Res, 2004. PMID 14960721, Free PMC Article
  5. Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. Agellon LB, et al. J Biol Chem, 2002 Jun 7. PMID 11967256

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055431.1 

    Range
    101..451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    6275600..6275950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version