Syt17 synaptotagmin XVII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt17provided by MGI
Official Full Name: synaptotagmin XVIIprovided by MGI
Primary source: MGI:MGI:104966
See related: Ensembl:ENSMUSG00000058420 AllianceGenome:MGI:104966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bk; sytXVII
Summary: Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; positive regulation of dendrite extension; and regulation of secretion by cell. Predicted to act upstream of or within cell differentiation. Located in trans-Golgi network. Is expressed in adrenal gland; male reproductive gland or organ; metanephros; and nervous system. Orthologous to human SYT17 (synaptotagmin 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 12.9), cortex adult (RPKM 9.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 63.44 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (117979936..118048120, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (118380713..118448583, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circadian expression and specific localization of synaptotagmin17 in the suprachiasmatic nucleus, the master circadian oscillator in mammals.
Title: Circadian expression and specific localization of synaptotagmin17 in the suprachiasmatic nucleus, the master circadian oscillator in mammals.
Study localized syt-17 in primary hippocampal neurons to two compartments: the Golgi complex in the soma and Rab5-positive early endosomes in neurites and concluded that syt-17 is a multifunctional regulator of intracellular protein trafficking in excitatory hippocampal neurons, modulating both neural development and synaptic physiology.
Title: Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.
The N-terminal domain of B/K protein contains a novel cysteine-based motif that allows B/K protein to localize in the trans-Golgi network.
Title: The N-terminal cysteine cluster is essential for membrane targeting of B/K protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489291

D7Mit7 (e-PCR), detects polymorphism
- UniSTS:131287

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium-ion regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptotagmin-17

Names: B/K protein; brain and kidney protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362179.2 → NP_001349108.1 synaptotagmin-17 isoform 2

Status: VALIDATED

Source sequence(s)

AC122912, AC125126

Consensus CDS

CCDS90319.1

UniProtKB/TrEMBL

A0A0N4SVG2, A0A140LJ89

Related

ENSMUSP00000145087.2, ENSMUST00000203796.4

Conserved Domains (2) summary

cd08390
Location:125 → 253

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:262 → 396

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
NM_001362180.2 → NP_001349109.1 synaptotagmin-17 isoform 2

Status: VALIDATED

Source sequence(s)

AC122912, AC125126

Consensus CDS

CCDS90319.1

UniProtKB/TrEMBL

A0A0N4SVG2, A0A140LJ89

Conserved Domains (2) summary

cd08390
Location:125 → 253

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:262 → 396

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
NM_001403643.1 → NP_001390572.1 synaptotagmin-17 isoform 2

Status: VALIDATED

Source sequence(s)

AC122912, AC125126

UniProtKB/TrEMBL

A0A0N4SVG2
NM_001403644.1 → NP_001390573.1 synaptotagmin-17 isoform 2

Status: VALIDATED

Source sequence(s)

AC122912, AC125126

UniProtKB/TrEMBL

A0A0N4SVG2
NM_001403645.1 → NP_001390574.1 synaptotagmin-17 isoform 3

Status: VALIDATED

Source sequence(s)

AC122912, AC125126

Related

ENSMUSP00000144987.2, ENSMUST00000203485.3
NM_138649.3 → NP_619590.1 synaptotagmin-17 isoform 1

See identical proteins and their annotated locations for NP_619590.1

Status: VALIDATED

Source sequence(s)

AC122912, AC125126

Consensus CDS

CCDS40103.1

UniProtKB/Swiss-Prot

Q3UXZ2, Q920M7

UniProtKB/TrEMBL

A0A140LJ89

Related

ENSMUSP00000080284.5, ENSMUST00000081574.8

Conserved Domains (2) summary

cd08390
Location:182 → 310

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:319 → 453

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

117979936..118048120 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152570.1 → XP_036008463.1 synaptotagmin-17 isoform X2

UniProtKB/TrEMBL

A0A0N4SV78

Conserved Domains (2) summary

cd08390
Location:229 → 357

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cl14603
Location:366 → 454

C2; C2 domain
XM_030241986.2 → XP_030097846.1 synaptotagmin-17 isoform X5

UniProtKB/TrEMBL

A0A0N4SVG2, A0A140LJ89

Conserved Domains (2) summary

cd08390
Location:125 → 253

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:262 → 396

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
XM_030241987.1 → XP_030097847.1 synaptotagmin-17 isoform X5

UniProtKB/TrEMBL

A0A0N4SVG2, A0A140LJ89

Related

ENSMUSP00000147122.2, ENSMUST00000203465.2

Conserved Domains (2) summary

cd08390
Location:125 → 253

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:262 → 396

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17