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Grk2 G protein-coupled receptor kinase 2 [ Castor canadensis (American beaver) ]

Gene ID: 109690706, updated on 14-Mar-2024

Summary

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Gene symbol
Grk2
Gene description
G protein-coupled receptor kinase 2
See related
Ensembl:ENSCCNG00000026800
Gene type
protein coding
RefSeq status
MODEL
Organism
Castor canadensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae; Castor
Also known as
ADRBK2
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
100 current C.can genome v1.0 (GCF_001984765.1) Unplaced Scaffold NW_017871048.1 (116139..125307, complement)

NW_017871048.1Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 3 Neighboring gene ankyrin repeat domain 13D

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_017871048.1 Unplaced Scaffold Reference C.can genome v1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor canadensis). Lok S, et al. G3 (Bethesda), 2017 Feb 9. PMID 28087693, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of the force of heart contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-adrenergic receptor kinase 1
Names
beta-adrenergic receptor kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Castor canadensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference C.can genome v1.0

Genomic

  1. NW_017871048.1 Reference C.can genome v1.0

    Range
    116139..125307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_020170176.1 → XP_020025765.1  beta-adrenergic receptor kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A250YKW7, A0A8B7V4T0
    Conserved Domains (3) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:593 → 710
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd14223
    Location:190 → 550
    STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2

  2. XM_020170177.1 → XP_020025766.1  beta-adrenergic receptor kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A250YKR9, A0A250YKW7
    Related
    ENSCCNP00000027758.1, ENSCCNT00000035108.1
    Conserved Domains (3) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:553 → 670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd14223
    Location:190 → 510
    STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2
Nucleotide Protein
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