Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts7provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 7provided by MGI
Primary source: MGI:MGI:1347346
See related: Ensembl:ENSMUSG00000032363 AllianceGenome:MGI:1347346
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADAM-TS7; ADAMTS7B
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent enzyme that degrades cartilage oligomeric matrix protein. The deficiency of the encoded protein decreases atherosclerosis in genetically hyperlipidemic mice and in response to vascular injury. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression: Broad expression in limb E14.5 (RPKM 11.2), subcutaneous fat pad adult (RPKM 9.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.1; 9 47.46 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (90041420..90082155)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (90162904..90200102)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.
Title: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.
ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice.
Title: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice.
ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries.
Title: ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries.
ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses.
Title: ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses.
Adamts7-/- Adamts12-/- mice, but not corresponding single-gene mutants, develop progressive heterotopic ossification (HO) in tendons with abnormal collagen fibrils, accompanied by reduced levels of the small leucine-rich proteoglycans which regulate collagen fibrillogenesis. These results suggest that Adamts7 and Adamts12 drive an innate pathway protective against hindlimb HO in mice.
Title: The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.
presents the expression levels of ADAMTS-7 and COMP in the decidual tissues of mice and humans suffering from SA.
Title: Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion.
Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis.
Title: Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice.
Adamts-7 deficiency substantially ameliorated neointima formation in mice at days 14 and 28 after injury. ADAMTS-7 inhibited both endothelial cell proliferation and migration.
Title: ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.
Mice lacking Adamts7, Ldlr, Apoe had less lesion formation in aortas and aortic roots vs controls and less neointimal formation after femoral wire injury. Adamts7 expression was induced by injury and hyperlipidemia.
Title: Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.
The overexpression of ADATMTS-7 might contribute to early inflammatory kidney damage associated with aging
Title: ADAMTS-7 expression increases in the early stage of angiotensin II-induced renal injury in elderly mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adamts7 (e-PCR), detects polymorphism
- UniSTS:532654

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in collagen fibril organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ossification involved in bone maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteoglycan metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 7

Names: COMPase; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7

NP_001003911.2

EC 3.4.24.-

NP_001298044.1

EC 3.4.24.-

NP_001313223.1

EC 3.4.24.-

NP_001313280.1

EC 3.4.24.-

XP_006510822.1

EC 3.4.24.-

XP_006510823.1

EC 3.4.24.-

XP_006510825.1

EC 3.4.24.-

XP_030099860.1

EC 3.4.24.-

XP_030099861.1

EC 3.4.24.-

XP_036010447.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003911.2 → NP_001003911.2 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 4.

Source sequence(s)

BC058991, BC076575, BY347798, CB246893

Consensus CDS

CCDS40724.1

UniProtKB/TrEMBL

B7ZNX1

Related

ENSMUSP00000108683.2, ENSMUST00000113060.3

Conserved Domains (5) summary

smart00209
Location:526 → 578

TSP1; Thrombospondin type 1 repeats

cd04273
Location:226 → 434

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:226 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:58 → 173

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 794

ADAM_spacer1; ADAM-TS Spacer 1
NM_001311115.1 → NP_001298044.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 4.

Source sequence(s)

BC058991, BQ748923, BU055903, BY347798, CA316195, CB246893, CF532146

Consensus CDS

CCDS81050.1

UniProtKB/TrEMBL

B7ZNX1, F6UD05

Related

ENSMUSP00000115972.3, ENSMUST00000147250.8

Conserved Domains (5) summary

smart00209
Location:526 → 578

TSP1; Thrombospondin type 1 repeats

cd04273
Location:226 → 434

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:226 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:58 → 173

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 794

ADAM_spacer1; ADAM-TS Spacer 1
NM_001326294.1 → NP_001313223.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 3

Status: REVIEWED

Source sequence(s)

BC058991, BC076575, BY347798

UniProtKB/TrEMBL

Q6PD18

Conserved Domains (2) summary

smart00209
Location:297 → 352

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:172 → 283

ADAM_spacer1; ADAM-TS Spacer 1
NM_001326351.1 → NP_001313280.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 4 preproprotein

Status: REVIEWED

Source sequence(s)

AC140392, BC058991, BC076575, BY347798, CB246893

Consensus CDS

CCDS85708.1

UniProtKB/Swiss-Prot

B2RUI8, E9QMY0, Q68SA9

UniProtKB/TrEMBL

E9PX36

Related

ENSMUSP00000108682.2, ENSMUST00000113059.8

Conserved Domains (6) summary

smart00209
Location:526 → 578

TSP1; Thrombospondin type 1 repeats

cd04273
Location:226 → 434

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:226 → 437

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:58 → 173

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 794

ADAM_spacer1; ADAM-TS Spacer 1

pfam15822
Location:1083 → 1334

MISS; MAPK-interacting and spindle-stabilizing protein-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

90041420..90082155

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510760.3 → XP_006510823.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X2

UniProtKB/TrEMBL

B7ZNX1

Conserved Domains (6) summary

smart00209
Location:526 → 578

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:1058 → 1344

PHA03247; large tegument protein UL36; Provisional

cd04273
Location:226 → 434

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:34 → 174

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 794

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:449 → 513

ADAM_CR_2; ADAM cysteine-rich domain
XM_030244000.2 → XP_030099860.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X3

UniProtKB/TrEMBL

Q6PD18

Conserved Domains (4) summary

smart00209
Location:54 → 106

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:593 → 931

PHA03247; large tegument protein UL36; Provisional

pfam05986
Location:211 → 322

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:2 → 41

ADAM_CR_2; ADAM cysteine-rich domain
XM_030244001.2 → XP_030099861.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X5

UniProtKB/TrEMBL

Q6PD18

Conserved Domains (4) summary

smart00209
Location:54 → 106

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:551 → 889

PHA03247; large tegument protein UL36; Provisional

pfam05986
Location:211 → 322

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:2 → 41

ADAM_CR_2; ADAM cysteine-rich domain
XM_036154554.1 → XP_036010447.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X6

Conserved Domains (6) summary

smart00209
Location:526 → 578

TSP1; Thrombospondin type 1 repeats

cd04273
Location:226 → 434

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:683 → 794

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:34 → 174

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:449 → 513

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:808 → 821

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_006510759.4 → XP_006510822.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1

UniProtKB/TrEMBL

E9PX36

Conserved Domains (6) summary

smart00209
Location:511 → 563

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:1050 → 1388

PHA03247; large tegument protein UL36; Provisional

cd04273
Location:211 → 419

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:19 → 159

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:668 → 779

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:434 → 498

ADAM_CR_2; ADAM cysteine-rich domain
XM_006510762.1 → XP_006510825.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X4

Conserved Domains (3) summary

smart00209
Location:297 → 352

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:554 → 892

PHA03247; large tegument protein UL36; Provisional

pfam05986
Location:172 → 283

ADAM_spacer1; ADAM-TS Spacer 1