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ZNF273 zinc finger protein 273 [ Homo sapiens (human) ]

Gene ID: 10793, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF273provided by HGNC
Official Full Name
zinc finger protein 273provided by HGNC
Primary source
HGNC:HGNC:13067
See related
Ensembl:ENSG00000198039 MIM:604756; AllianceGenome:HGNC:13067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF9
Summary
This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 16.5), bone marrow (RPKM 2.0) and 6 other tissues See more
Orthologs
all
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Genomic context

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Location:
7q11.21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64877603..64937316)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (66083757..66137245)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64337981..64391359)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64315844-64316400 Neighboring gene selenophosphate synthetase 1 pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64348006-64348724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64348725-64349442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64350161-64350877 Neighboring gene uncharacterized LOC441239 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64362646-64363518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64363519-64364391 Neighboring gene vomeronasal 1 receptor 42 pseudogene Neighboring gene metadherin pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64428091-64428834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64428835-64429578 Neighboring gene ERV3-1-ZNF117 readthrough Neighboring gene MPRA-validated peak6534 silencer Neighboring gene vomeronasal 1 receptor 43 pseudogene Neighboring gene zinc finger protein 117

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  2. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Seo BA, et al. Neuron, 2021 Dec 1. PMID 34644545, Free PMC Article
  3. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
  4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 273
Names
zinc finger protein 9
zinc finger protein HZF9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385643.1 → NP_001372572.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  2. NM_001385644.1 → NP_001372573.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. NM_001385645.1 → NP_001372574.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. NM_001385646.1 → NP_001372575.1  zinc finger protein 273 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (2) summary
    COG5048
    Location:94 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:251 → 271
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001385647.1 → NP_001372576.1  zinc finger protein 273 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (1) summary
    smart00349
    Location:37 → 97
    KRAB; krueppel associated box

  6. NM_001385649.1 → NP_001372578.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  7. NM_001385650.1 → NP_001372579.1  zinc finger protein 273 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (1) summary
    smart00349
    Location:37 → 97
    KRAB; krueppel associated box

  8. NM_001385652.1 → NP_001372581.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  9. NM_001388021.1 → NP_001374950.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  10. NM_021148.3 → NP_066971.2  zinc finger protein 273 isoform 1

    See identical proteins and their annotated locations for NP_066971.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092161
    Consensus CDS
    CCDS5528.2
    UniProtKB/Swiss-Prot
    B3KQZ5, Q14593, Q6P3V4
    Related
    ENSP00000418719.1, ENST00000476120.2
    Conserved Domains (5) summary
    smart00349
    Location:37 → 97
    KRAB; krueppel associated box
    COG5048
    Location:191 → 537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:348 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 76
    KRAB; KRAB box
    pfam13465
    Location:501 → 525
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_169738.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  2. NR_169741.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  3. NR_169742.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  4. NR_169743.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  5. NR_169744.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  6. NR_169745.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  7. NR_169746.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161

  8. NR_169747.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092161

  9. NR_169748.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092161

  10. NR_170871.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Related
    ENST00000489672.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    64877603..64937316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419800.1 → XP_047275756.1  zinc finger protein 273 isoform X2

  2. XM_047419813.1 → XP_047275769.1  zinc finger protein 273 isoform X2

  3. XM_047419803.1 → XP_047275759.1  zinc finger protein 273 isoform X2

  4. XM_047419809.1 → XP_047275765.1  zinc finger protein 273 isoform X2

  5. XM_047419812.1 → XP_047275768.1  zinc finger protein 273 isoform X2

  6. XM_047419814.1 → XP_047275770.1  zinc finger protein 273 isoform X2

  7. XM_047419806.1 → XP_047275762.1  zinc finger protein 273 isoform X2

  8. XM_047419817.1 → XP_047275773.1  zinc finger protein 273 isoform X2

  9. XM_047419821.1 → XP_047275777.1  zinc finger protein 273 isoform X2

  10. XM_047419804.1 → XP_047275760.1  zinc finger protein 273 isoform X2

  11. XM_047419818.1 → XP_047275774.1  zinc finger protein 273 isoform X2

  12. XM_024446635.2 → XP_024302403.1  zinc finger protein 273 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:126 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  13. XM_047419810.1 → XP_047275766.1  zinc finger protein 273 isoform X2

  14. XM_047419807.1 → XP_047275763.1  zinc finger protein 273 isoform X2

  15. XM_047419819.1 → XP_047275775.1  zinc finger protein 273 isoform X2

  16. XM_047419815.1 → XP_047275771.1  zinc finger protein 273 isoform X2

  17. XM_047419822.1 → XP_047275778.1  zinc finger protein 273 isoform X2

  18. XM_047419811.1 → XP_047275767.1  zinc finger protein 273 isoform X2

  19. XM_047419802.1 → XP_047275758.1  zinc finger protein 273 isoform X2

  20. XM_047419808.1 → XP_047275764.1  zinc finger protein 273 isoform X2

  21. XM_047419801.1 → XP_047275757.1  zinc finger protein 273 isoform X2

  22. XM_047419805.1 → XP_047275761.1  zinc finger protein 273 isoform X2

  23. XM_047419816.1 → XP_047275772.1  zinc finger protein 273 isoform X2

  24. XM_047419820.1 → XP_047275776.1  zinc finger protein 273 isoform X2

  25. XM_047419799.1 → XP_047275755.1  zinc finger protein 273 isoform X1

RNA

  1. XR_007059982.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    66083757..66137245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357132.1 → XP_054213107.1  zinc finger protein 273 isoform X2

  2. XM_054357126.1 → XP_054213101.1  zinc finger protein 273 isoform X2

  3. XM_054357133.1 → XP_054213108.1  zinc finger protein 273 isoform X2

  4. XM_054357130.1 → XP_054213105.1  zinc finger protein 273 isoform X2

  5. XM_054357138.1 → XP_054213113.1  zinc finger protein 273 isoform X2

  6. XM_054357134.1 → XP_054213109.1  zinc finger protein 273 isoform X2

  7. XM_054357127.1 → XP_054213102.1  zinc finger protein 273 isoform X2

  8. XM_054357125.1 → XP_054213100.1  zinc finger protein 273 isoform X2

  9. XM_054357131.1 → XP_054213106.1  zinc finger protein 273 isoform X2

  10. XM_054357129.1 → XP_054213104.1  zinc finger protein 273 isoform X2

  11. XM_054357137.1 → XP_054213112.1  zinc finger protein 273 isoform X2

  12. XM_054357136.1 → XP_054213111.1  zinc finger protein 273 isoform X2

  13. XM_054357135.1 → XP_054213110.1  zinc finger protein 273 isoform X2

  14. XM_054357139.1 → XP_054213114.1  zinc finger protein 273 isoform X2

  15. XM_054357128.1 → XP_054213103.1  zinc finger protein 273 isoform X2

  16. XM_054357124.1 → XP_054213099.1  zinc finger protein 273 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033548.1: Suppressed sequence

    Description
    NM_033548.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NR_003099.1: Suppressed sequence

    Description
    NR_003099.1: This RefSeq was removed because it is now thought that this transcript is protein coding.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14593.3 GenPept UniProtKB/Swiss-Prot:Q14593

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