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Ssr1 signal sequence receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 107513, updated on 21-Apr-2024

Summary

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Official Symbol
Ssr1provided by MGI
Official Full Name
signal sequence receptor, alphaprovided by MGI
Primary source
MGI:MGI:105082
See related
Ensembl:ENSMUSG00000021427 AllianceGenome:MGI:105082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSR; TRAPA; 6330400D04; 2510001K09Rik
Summary
Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; bone; genitourinary system; respiratory system; and tail mesenchyme. Orthologous to human SSR1 (signal sequence receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 16.8), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.3; 13 17.86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38155377..38178184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (37971401..37994208, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37870871-37870980 Neighboring gene predicted gene, 31600 Neighboring gene STARR-positive B cell enhancer mm9_chr13:37884809-37885110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37893604-37893840 Neighboring gene ras responsive element binding protein 1 Neighboring gene predicted gene, 46411 Neighboring gene STARR-positive B cell enhancer ABC_E1461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37972487-37972670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37974410-37974611 Neighboring gene STARR-seq mESC enhancer starr_34234 Neighboring gene STARR-positive B cell enhancer ABC_E11541 Neighboring gene STARR-positive B cell enhancer ABC_E7227 Neighboring gene STARR-positive B cell enhancer ABC_E10789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38086110-38086293 Neighboring gene predicted gene, 52041 Neighboring gene STARR-positive B cell enhancer ABC_E9396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38129215-38129324 Neighboring gene cancer antigen 1 Neighboring gene RIO kinase 1 Neighboring gene STARR-seq mESC enhancer starr_34240 Neighboring gene STARR-seq mESC enhancer starr_34241 Neighboring gene desmoplakin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Unexpected behavior of a gene trap vector comprising a fusion between the Sh ble and the lacZ genes. Camus A, et al. Mol Reprod Dev, 1996 Nov. PMID 8916035
  2. Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects. Mesbah K, et al. Mol Cell Biol, 2006 Oct. PMID 17015483, Free PMC Article
  3. Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. Antony C, et al. J Cell Biol, 1995 Aug. PMID 7642711, Free PMC Article
  4. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Zhang B, et al. Blood, 2011 Sep 22. PMID 21795745, Free PMC Article
  5. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. Bard-Chapeau EA, et al. PLoS One, 2014. PMID 24586749, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAPalpha could be involved in translocation of factors necessary for maturation of endocardial cushions
    Title: Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translocon-associated protein subunit alpha
Names
SSR-alpha
TRAP-alpha
signal sequence receptor subunit alpha
translocon-associated protein alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360842.1 → NP_001347771.1  translocon-associated protein subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT010477
    UniProtKB/TrEMBL
    A0A286YCT4
    Related
    ENSMUSP00000153120.2, ENSMUST00000225246.2
    Conserved Domains (1) summary
    pfam03896
    Location:21 → 285
    TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit

  2. NM_025965.4 → NP_080241.3  translocon-associated protein subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_080241.3

    Status: VALIDATED

    Source sequence(s)
    AK010884, BB619494, CT010477
    Consensus CDS
    CCDS26459.1
    UniProtKB/Swiss-Prot
    Q3TIM3, Q99MP2, Q9CY50
    UniProtKB/TrEMBL
    Q3TV94
    Related
    ENSMUSP00000021864.7, ENSMUST00000021864.8
    Conserved Domains (1) summary
    pfam03896
    Location:18 → 280
    TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    38155377..38178184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY50.1 GenPept UniProtKB/Swiss-Prot:Q9CY50

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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