Gm45935 predicted gene, 45935 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gm45935provided by MGI
Official Full Name: predicted gene, 45935provided by MGI
Primary source: MGI:MGI:5825572
See related: AllianceGenome:MGI:5825572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Setdb2-phf11c
Summary: This gene represents naturally-occurring readthrough transcription between the upstream Setdb2 (SET domain, bifurcated 2) gene to the downstream Phf11c (PHD finger protein 11C) gene. Some transcripts may also extend to the Phf11d (PHD finger protein 11D) gene. Readthrough transcripts may encode fusion proteins with similarity to proteins encoded by each of the individual genes. [provided by RefSeq, Mar 2016]
Expression: Ubiquitous expression in liver E14 (RPKM 2.5), thymus adult (RPKM 2.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (59618282..59678329, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (59380833..59440880, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PCR detection of readthrough transcription at human ortholog
Title: Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

Submit: New GeneRIF Correction

General gene information

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Readthrough Gm45935

Included genes: Phf11d, Setdb2, Phf11c

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H3K9me2 methyltransferase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Setdb2-Phf11c protein

Names: Setdb2-Phf11-1-Phf11-2 fusion; Setdb2-Phf11c readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320725.1 → NP_001307654.1 Setdb2-Phf11c protein

Status: VALIDATED

Source sequence(s)

AC114007

UniProtKB/TrEMBL

B4XVP6, B4XVP7

Conserved Domains (4) summary

smart00317
Location:612 → 674

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd01395
Location:152 → 212

HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...

pfam05033
Location:234 → 346

Pre-SET; Pre-SET motif

cl22851
Location:700 → 813

PHD_SF; PHD finger superfamily