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Psmg2 proteasome (prosome, macropain) assembly chaperone 2 [ Mus musculus (house mouse) ]

Gene ID: 107047, updated on 5-Mar-2024

Summary

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Official Symbol
Psmg2provided by MGI
Official Full Name
proteasome (prosome, macropain) assembly chaperone 2provided by MGI
Primary source
MGI:MGI:1922901
See related
Ensembl:ENSMUSG00000024537 AllianceGenome:MGI:1922901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clast3; Tnfsf5ip1; 1700017I17Rik
Summary
Predicted to enable molecular adaptor activity. Acts upstream of or within mitotic spindle assembly checkpoint signaling and negative regulation of apoptotic process. Located in nucleus. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 23.8), CNS E11.5 (RPKM 21.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 40.05 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67774657..67787251)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67641587..67654181)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene spire type actin nucleation factor 1 Neighboring gene STARR-seq mESC enhancer starr_44907 Neighboring gene predicted gene, 17669 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67771962-67772263 Neighboring gene centrosomal protein 76 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene STARR-positive B cell enhancer ABC_E11000 Neighboring gene STARR-positive B cell enhancer ABC_E8723 Neighboring gene STARR-seq mESC enhancer starr_44912 Neighboring gene predicted gene, 46626

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. Bahar R, et al. J Biol Chem, 2002 Oct 18. PMID 12147697
  2. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
  3. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Koss M, et al. Dev Cell, 2012 May 15. PMID 22560297, Free PMC Article
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proteasome assembly chaperone 2
Names
CD40 ligand-activated specific transcript 3
tumor necrosis factor superfamily, member 5-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368147.1 → NP_001355076.1  proteasome assembly chaperone 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC108434, AC120410
    Consensus CDS
    CCDS89268.1
    Related
    ENSMUSP00000157785.2, ENSMUST00000235799.2

  2. NM_134138.2 → NP_598899.1  proteasome assembly chaperone 2 isoform 1

    See identical proteins and their annotated locations for NP_598899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK077569, AW123048, BY012642
    Consensus CDS
    CCDS29324.1
    UniProtKB/Swiss-Prot
    Q3TII5, Q3UXH7, Q8C1R5, Q91YJ0, Q9EST4
    Related
    ENSMUSP00000025418.4, ENSMUST00000025418.4
    Conserved Domains (1) summary
    pfam09754
    Location:17 → 126
    PAC2; PAC2 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67774657..67787251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EST4.1 GenPept UniProtKB/Swiss-Prot:Q9EST4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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