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Kctd9 potassium channel tetramerisation domain containing 9 [ Mus musculus (house mouse) ]

Gene ID: 105440, updated on 11-Apr-2024

Summary

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Official Symbol
Kctd9provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 9provided by MGI
Primary source
MGI:MGI:2145579
See related
Ensembl:ENSMUSG00000034327 AllianceGenome:MGI:2145579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cullin family protein binding activity; identical protein binding activity; and protein self-association. Predicted to be involved in intracellular signal transduction and protein homooligomerization. Is expressed in brain. Orthologous to human KCTD9 (potassium channel tetramerization domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.9), bladder adult (RPKM 5.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Kctd9 in Genome Data Viewer
Location:
14 D1; 14 34.66 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67953536..67979760)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (67716086..67742310)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24981 Neighboring gene STARR-seq mESC enhancer starr_37015 Neighboring gene cell division cycle associated 2 Neighboring gene STARR-seq mESC enhancer starr_37018 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene dedicator of cytokinesis 5 Neighboring gene STARR-seq mESC enhancer starr_37020 Neighboring gene microRNA 6539

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function. Zhang X, et al. Front Immunol, 2019. PMID 31024568, Free PMC Article
  2. Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice. Zhang X, et al. BMC Immunol, 2018 Jun 25. PMID 29940856, Free PMC Article
  3. [KCTD9, a novel potassium channel related gene, was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3]. Zhou YY, et al. Zhonghua Gan Zang Bing Za Zhi, 2011 Nov. PMID 22433305
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
    Title: Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
  2. Interference with potassium channel tetramerisation domain containing 9 (KCTD9) expression exert beneficial effect in viral fulminant hepatitis therapy, which may be mediated by impairment of NK cell activation.
    Title: Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice.
  3. A novel potassium channel gene KCTD9 was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3.
    Title: [KCTD9, a novel potassium channel related gene, was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111028.1 → NP_001104498.1  BTB/POZ domain-containing protein KCTD9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI854539, AK087312, AK158922
    Consensus CDS
    CCDS49531.1
    UniProtKB/TrEMBL
    A0AA74KUV6, E9PUA6
    Related
    ENSMUSP00000114489.2, ENSMUST00000150768.8
    Conserved Domains (5) summary
    smart00225
    Location:90 → 191
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00805
    Location:338 → 377
    Pentapeptide; Pentapeptide repeats (8 copies)
    pfam11834
    Location:2 → 64
    KHA; KHA, dimerization domain of potassium ion channel
    pfam13599
    Location:310 → 384
    Pentapeptide_4; Pentapeptide repeats (9 copies)
    cl02518
    Location:91 → 181
    BTB; BTB/POZ domain

  2. NM_001285933.1 → NP_001272862.1  BTB/POZ domain-containing protein KCTD9 isoform c

    See identical proteins and their annotated locations for NP_001272862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AI854539, AK087312, AK158922
    UniProtKB/Swiss-Prot
    Q80UN1
    Conserved Domains (2) summary
    COG1357
    Location:54 → 264
    YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
    cl38908
    Location:1 → 74
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  3. NM_134073.2 → NP_598834.2  BTB/POZ domain-containing protein KCTD9 isoform b

    See identical proteins and their annotated locations for NP_598834.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AI854539, AK158922
    Consensus CDS
    CCDS27230.2
    UniProtKB/Swiss-Prot
    Q3TLH9, Q3TY35, Q80UN1
    Related
    ENSMUSP00000077200.7, ENSMUST00000078053.13
    Conserved Domains (5) summary
    smart00225
    Location:90 → 191
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00805
    Location:288 → 327
    Pentapeptide; Pentapeptide repeats (8 copies)
    pfam11834
    Location:2 → 64
    KHA; KHA, dimerization domain of potassium ion channel
    pfam13599
    Location:260 → 334
    Pentapeptide_4; Pentapeptide repeats (9 copies)
    cl02518
    Location:91 → 181
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    67953536..67979760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518343.4 → XP_006518406.1  BTB/POZ domain-containing protein KCTD9 isoform X1

    See identical proteins and their annotated locations for XP_006518406.1

    Related
    ENSMUSP00000120440.2, ENSMUST00000152243.8
    Conserved Domains (2) summary
    COG1357
    Location:54 → 264
    YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
    cl38908
    Location:1 → 74
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UN1.1 GenPept UniProtKB/Swiss-Prot:Q80UN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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