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Rab15 RAB15, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 104886, updated on 21-Apr-2024

Summary

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Official Symbol
Rab15provided by MGI
Official Full Name
RAB15, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1916865
See related
Ensembl:ENSMUSG00000021062 AllianceGenome:MGI:1916865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310012G06Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; protein localization to plasma membrane; and secretion by cell. Predicted to act upstream of or within protein transport. Predicted to be located in cilium; endosome membrane; and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Is expressed in several structures, including 1st branchial arch; cerebellum external granule cell layer; embryo endoderm; neural tube; and vibrissa. Orthologous to human RAB15 (RAB15, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 9.0), cortex adult (RPKM 7.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C3; 12 33.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76844734..76869532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76797960..76822759, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32533 Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2 Neighboring gene STARR-seq mESC enhancer starr_32534 Neighboring gene predicted gene, 34988 Neighboring gene STARR-positive B cell enhancer ABC_E2389 Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene predicted gene, 46357 Neighboring gene predicted gene, 46358 Neighboring gene STARR-seq mESC enhancer starr_32542

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
  2. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Pyrgaki C, et al. Dev Biol, 2011 May 1. PMID 21377456, Free PMC Article
  3. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Walentin K, et al. Development, 2015 Mar 15. PMID 25758223, Free PMC Article
  4. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, et al. Dev Biol, 2007 Apr 15. PMID 17328885
  5. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347405.1 → NP_001334334.1  ras-related protein Rab-15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132331, AI840042, AK158637, AK158768
    Consensus CDS
    CCDS83970.1
    UniProtKB/TrEMBL
    D3YTZ8, D3YWS1
    Related
    ENSMUSP00000113299.2, ENSMUST00000121716.8
    Conserved Domains (1) summary
    cl38936
    Location:1 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001347406.1 → NP_001334335.1  ras-related protein Rab-15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132331, AI840042, AK158637, AK158768
    Consensus CDS
    CCDS83970.1
    UniProtKB/TrEMBL
    D3YTZ8, D3YWS1
    Related
    ENSMUSP00000112789.2, ENSMUST00000118604.8
    Conserved Domains (1) summary
    cl38936
    Location:1 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001347407.1 → NP_001334336.1  ras-related protein Rab-15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI840042, AK158637, AK158768, BY239543
    Consensus CDS
    CCDS83970.1
    UniProtKB/TrEMBL
    D3YTZ8, D3YWS1
    Conserved Domains (1) summary
    cl38936
    Location:1 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_134050.5 → NP_598811.3  ras-related protein Rab-15 isoform 1

    See identical proteins and their annotated locations for NP_598811.3

    Status: VALIDATED

    Source sequence(s)
    AI840042, AK158637, AK158768, BY237353
    Consensus CDS
    CCDS25997.1
    UniProtKB/Swiss-Prot
    Q8K386
    UniProtKB/TrEMBL
    Q0PD40, Q3TYH2
    Related
    ENSMUSP00000021459.8, ENSMUST00000021459.14
    Conserved Domains (1) summary
    cd04117
    Location:9 → 172
    Rab15; Rab GTPase family 15 (Rab15)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76844734..76869532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_381469.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K386.1 GenPept UniProtKB/Swiss-Prot:Q8K386

Gene LinkOut

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