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ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Chelonia mydas (Green sea turtle) ]

Gene ID: 102940614, updated on 10-Mar-2024

Summary

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Gene symbol
ARHGEF11
Gene description
Rho guanine nucleotide exchange factor 11
Locus tag
UY3_11568
See related
EnsemblRapid:ENSCMYG00015002698
Gene type
protein coding
RefSeq status
MODEL
Organism
Chelonia mydas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; Americhelydia; Chelonioidea; Cheloniidae; Chelonia
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
43
Annotation release Status Assembly Chr Location
103 current rCheMyd1.pri.v2 (GCF_015237465.2) 24 NC_051264.2 (3860213..3941716)
102 previous assembly rCheMyd1.pri (GCF_015237465.1) 21 NC_051261.1 (3856402..3941685)

Chromosome 24 - NC_051264.2Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 3 Neighboring gene ETS variant transcription factor 3 like Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic receptor tyrosine kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers. Duffy DJ, et al. Commun Biol, 2018. PMID 30271945, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chelonia mydas Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference rCheMyd1.pri.v2 Primary Assembly

Genomic

  1. NC_051264.2 Reference rCheMyd1.pri.v2 Primary Assembly

    Range
    3860213..3941716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_043535262.1 → XP_043391197.1  rho guanine nucleotide exchange factor 11 isoform X1

    Conserved Domains (5) summary
    cd08753
    Location:345 → 489
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:56 → 132
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1295 → 1493
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:791 → 977
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:995 → 1136
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  2. XM_043535267.1 → XP_043391202.1  rho guanine nucleotide exchange factor 11 isoform X8

    Conserved Domains (5) summary
    cd08753
    Location:345 → 489
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:56 → 132
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1282 → 1462
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:791 → 977
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:995 → 1136
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  3. XM_043535264.1 → XP_043391199.1  rho guanine nucleotide exchange factor 11 isoform X3

    Conserved Domains (5) summary
    cd08753
    Location:345 → 489
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:56 → 132
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1285 → 1483
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:781 → 967
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:985 → 1126
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  4. XM_043535263.1 → XP_043391198.1  rho guanine nucleotide exchange factor 11 isoform X2

    Conserved Domains (5) summary
    cd08753
    Location:345 → 489
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:56 → 132
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1294 → 1492
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:790 → 976
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:994 → 1135
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  5. XM_043535265.1 → XP_043391200.1  rho guanine nucleotide exchange factor 11 isoform X4

    Conserved Domains (5) summary
    cd08753
    Location:345 → 489
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:56 → 132
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1284 → 1482
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:780 → 966
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:984 → 1125
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  6. XM_037882914.2 → XP_037738842.1  rho guanine nucleotide exchange factor 11 isoform X5

    Conserved Domains (5) summary
    cd08753
    Location:334 → 478
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:45 → 121
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1284 → 1482
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:780 → 966
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:984 → 1125
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  7. XM_037882915.2 → XP_037738843.1  rho guanine nucleotide exchange factor 11 isoform X7

    Related
    ENSCMYP00015004059.1, ENSCMYT00015005015.1
    Conserved Domains (5) summary
    cd08753
    Location:334 → 478
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:45 → 121
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1283 → 1481
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:779 → 965
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:983 → 1124
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  8. XM_043535268.1 → XP_043391203.1  rho guanine nucleotide exchange factor 11 isoform X9

    Related
    ENSCMYP00015004054.1, ENSCMYT00015005010.1
    Conserved Domains (5) summary
    cd08753
    Location:334 → 478
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:45 → 121
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1270 → 1450
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:779 → 965
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:983 → 1124
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  9. XM_043535266.1 → XP_043391201.1  rho guanine nucleotide exchange factor 11 isoform X6

    Conserved Domains (5) summary
    cd08753
    Location:334 → 478
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:45 → 121
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK07764
    Location:1284 → 1482
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00160
    Location:780 → 966
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:984 → 1125
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
Nucleotide Protein
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